Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction
Placental infections with Plasmodium falciparum are associated with fetal growth restriction resulting in low birth weight (LBW). The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesi...
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| creator | Silver, Karlee L Conroy, Andrea L Leke, Rose G F Leke, Robert J I Gwanmesia, Philomina Molyneux, Malcolm E Taylor, Diane Wallace Wallace, Diane Taylor Rogerson, Stephen J Kain, Kevin C |
| description | Placental infections with Plasmodium falciparum are associated with fetal growth restriction resulting in low birth weight (LBW). The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesis. Soluble endoglin (sEng), a soluble receptor of transforming growth factor (TGF)-β previously associated with preeclampsia in pregnant women and with severe malaria in children, regulates the immune system and influences angiogenesis. We hypothesized that sEng may play a role in development of LBW associated with placental malaria (PM). Plasma levels of sEng were measured in women (i) followed prospectively throughout pregnancy in Cameroon (n = 52), and (ii) in a case-control study at delivery in Malawi (n = 479). The relationships between sEng levels and gravidity, peripheral and placental parasitemia, gestational age, and adverse outcomes of PM including maternal anemia and LBW were determined. In the longitudinal cohort from Cameroon, 28 of 52 women (54%) experienced at least one malaria infection during pregnancy. In Malawi we enrolled two aparasitemic gravidity-matched controls for every case with PM. sEng levels varied over the course of gestation and were significantly higher in early and late gestation as compared to delivery (P |
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The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesis. Soluble endoglin (sEng), a soluble receptor of transforming growth factor (TGF)-β previously associated with preeclampsia in pregnant women and with severe malaria in children, regulates the immune system and influences angiogenesis. We hypothesized that sEng may play a role in development of LBW associated with placental malaria (PM). Plasma levels of sEng were measured in women (i) followed prospectively throughout pregnancy in Cameroon (n = 52), and (ii) in a case-control study at delivery in Malawi (n = 479). The relationships between sEng levels and gravidity, peripheral and placental parasitemia, gestational age, and adverse outcomes of PM including maternal anemia and LBW were determined. In the longitudinal cohort from Cameroon, 28 of 52 women (54%) experienced at least one malaria infection during pregnancy. In Malawi we enrolled two aparasitemic gravidity-matched controls for every case with PM. sEng levels varied over the course of gestation and were significantly higher in early and late gestation as compared to delivery (P<0.006 and P<0.0001, respectively). Circulating sEng levels were higher in primigravidae than multigravidae from both Cameroon and Malawi, irrespective of malarial infection status (p<0.046 and p<0.001, respectively). Peripheral parasitemia in Cameroonian women and PM in Malawian women were each associated with elevated sEng levels following correction for gestational age and gravidity (p = 0.006 and p = 0.033, respectively). Increased sEng was also associated with the delivery of LBW infants in primigravid Malawian women (p = 0.017); the association was with fetal growth restriction (p = 0.003) but not pre-term delivery (p = 0.286). Increased circulating maternal sEng levels are associated with P. falciparum infection in pregnancy and with fetal growth restriction in primigravidae with PM.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0024985</identifier><identifier>PMID: 21966395</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Anemia ; Angiogenesis ; Antigens, CD - blood ; Biology ; Biomedical research ; Birth control ; Birth weight ; Cameroon ; Case-Control Studies ; Children ; Chondroitin sulfate ; Consent ; Endoglin ; Ethics ; Female ; Fetal development ; Fetal Growth Retardation - blood ; Fetuses ; Gestation ; Gestational Age ; Growth ; Health aspects ; Health care networks ; Hospitals ; Humans ; Immune system ; Infants ; Infection ; Infections ; Inflammation ; Laboratories ; Low birth weight ; Malaria ; Malaria - blood ; Malawi ; Medicine ; Neovascularization, Physiologic ; Parasitemia ; Parasites ; Placenta ; Placenta - parasitology ; Plasma levels ; Plasmodium falciparum ; Pre-eclampsia ; Preeclampsia ; Pregnancy ; Pregnancy Complications, Parasitic ; Pregnancy Outcome ; Pregnant women ; Prospective Studies ; Receptors, Cell Surface - blood ; Sexual behavior ; Stem cells ; Studies ; Syphilis ; Transforming Growth Factor beta - metabolism ; Transforming growth factor-a ; Transforming growth factors ; Tropical diseases ; Ultrasonic imaging ; Vector-borne diseases ; Womens health</subject><ispartof>PloS one, 2011-09, Vol.6 (9), p.e24985-e24985</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Silver et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Silver et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-453c9bec3cb30a6fa2339bf42a591566a12b77c82df48b0bf6105a7a5c7b944e3</citedby><cites>FETCH-LOGICAL-c691t-453c9bec3cb30a6fa2339bf42a591566a12b77c82df48b0bf6105a7a5c7b944e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178568/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178568/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21966395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silver, Karlee L</creatorcontrib><creatorcontrib>Conroy, Andrea L</creatorcontrib><creatorcontrib>Leke, Rose G F</creatorcontrib><creatorcontrib>Leke, Robert J I</creatorcontrib><creatorcontrib>Gwanmesia, Philomina</creatorcontrib><creatorcontrib>Molyneux, Malcolm E</creatorcontrib><creatorcontrib>Taylor, Diane Wallace</creatorcontrib><creatorcontrib>Wallace, Diane Taylor</creatorcontrib><creatorcontrib>Rogerson, Stephen J</creatorcontrib><creatorcontrib>Kain, Kevin C</creatorcontrib><title>Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Placental infections with Plasmodium falciparum are associated with fetal growth restriction resulting in low birth weight (LBW). The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesis. Soluble endoglin (sEng), a soluble receptor of transforming growth factor (TGF)-β previously associated with preeclampsia in pregnant women and with severe malaria in children, regulates the immune system and influences angiogenesis. We hypothesized that sEng may play a role in development of LBW associated with placental malaria (PM). Plasma levels of sEng were measured in women (i) followed prospectively throughout pregnancy in Cameroon (n = 52), and (ii) in a case-control study at delivery in Malawi (n = 479). The relationships between sEng levels and gravidity, peripheral and placental parasitemia, gestational age, and adverse outcomes of PM including maternal anemia and LBW were determined. In the longitudinal cohort from Cameroon, 28 of 52 women (54%) experienced at least one malaria infection during pregnancy. In Malawi we enrolled two aparasitemic gravidity-matched controls for every case with PM. sEng levels varied over the course of gestation and were significantly higher in early and late gestation as compared to delivery (P<0.006 and P<0.0001, respectively). Circulating sEng levels were higher in primigravidae than multigravidae from both Cameroon and Malawi, irrespective of malarial infection status (p<0.046 and p<0.001, respectively). Peripheral parasitemia in Cameroonian women and PM in Malawian women were each associated with elevated sEng levels following correction for gestational age and gravidity (p = 0.006 and p = 0.033, respectively). Increased sEng was also associated with the delivery of LBW infants in primigravid Malawian women (p = 0.017); the association was with fetal growth restriction (p = 0.003) but not pre-term delivery (p = 0.286). Increased circulating maternal sEng levels are associated with P. falciparum infection in pregnancy and with fetal growth restriction in primigravidae with PM.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anemia</subject><subject>Angiogenesis</subject><subject>Antigens, CD - blood</subject><subject>Biology</subject><subject>Biomedical research</subject><subject>Birth control</subject><subject>Birth weight</subject><subject>Cameroon</subject><subject>Case-Control Studies</subject><subject>Children</subject><subject>Chondroitin sulfate</subject><subject>Consent</subject><subject>Endoglin</subject><subject>Ethics</subject><subject>Female</subject><subject>Fetal development</subject><subject>Fetal Growth Retardation - blood</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Gestational Age</subject><subject>Growth</subject><subject>Health aspects</subject><subject>Health care networks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infants</subject><subject>Infection</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Laboratories</subject><subject>Low birth weight</subject><subject>Malaria</subject><subject>Malaria - blood</subject><subject>Malawi</subject><subject>Medicine</subject><subject>Neovascularization, Physiologic</subject><subject>Parasitemia</subject><subject>Parasites</subject><subject>Placenta</subject><subject>Placenta - parasitology</subject><subject>Plasma levels</subject><subject>Plasmodium falciparum</subject><subject>Pre-eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Parasitic</subject><subject>Pregnancy Outcome</subject><subject>Pregnant women</subject><subject>Prospective Studies</subject><subject>Receptors, Cell Surface - blood</subject><subject>Sexual behavior</subject><subject>Stem cells</subject><subject>Studies</subject><subject>Syphilis</subject><subject>Transforming Growth Factor beta - metabolism</subject><subject>Transforming growth factor-a</subject><subject>Transforming growth factors</subject><subject>Tropical diseases</subject><subject>Ultrasonic imaging</subject><subject>Vector-borne diseases</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk8tu1DAUhiMEoqXwBggiIYFYzGDHl8QbpGrEpVJRJW5b69hxMq4ce2onHXgJnhmnnVYd1AXyItbJ9_9Ofp9TFM8xWmJS43fnYYoe3HITvFkiVFHRsAfFIRakWvAKkYd39gfFk5TOEWKk4fxxcVBhwTkR7LD4s7JRTw5G6_syBTcpZ0rj29A760tnLo1LZd5touk9-LHchsH4ubKCwcQQfAm-Lb-Ag61dLCCloG12Cz6VWzuuy40DbfwIrhwyEy1c8Z2ZK30M24xEk8Zo9Sx6WjzqwCXzbPc8Kn58_PB99XlxevbpZHV8utBc4HFBGdFCGU20Igh4BxUhQnW0AiYw4xxwpepaN1Xb0UYh1XGMGNTAdK0EpYYcFS-vfTcuJLmLMklMUCMI4gRn4uSaaAOcy020A8TfMoCVV4UQewlxtNoZ2baEGc24ZtDSltaqUgK1VPEOad2Byl7vd6dNajDtnEcEt2e6_8bbtezDpSS4bhhvssGbnUEMF1OOSw42aeMceBOmJBvBK4opIZl89Q95_8_tqB7y91vfhXysnj3lMa15U9eCzV7Le6i8WjNYnduus7m-J3i7J8jMaH6NPUwpyZNvX_-fPfu5z76-w64NuHE99-pVm-2D9BrUMaQUTXebMUZynpqbNOQ8NXI3NVn24u793IpuxoT8BUt5Fj4</recordid><startdate>20110922</startdate><enddate>20110922</enddate><creator>Silver, Karlee L</creator><creator>Conroy, Andrea L</creator><creator>Leke, Rose G F</creator><creator>Leke, Robert J I</creator><creator>Gwanmesia, Philomina</creator><creator>Molyneux, Malcolm E</creator><creator>Taylor, Diane Wallace</creator><creator>Wallace, Diane Taylor</creator><creator>Rogerson, Stephen J</creator><creator>Kain, Kevin C</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110922</creationdate><title>Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction</title><author>Silver, Karlee L ; Conroy, Andrea L ; Leke, Rose G F ; Leke, Robert J I ; Gwanmesia, Philomina ; Molyneux, Malcolm E ; Taylor, Diane Wallace ; Wallace, Diane Taylor ; Rogerson, Stephen J ; Kain, Kevin C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-453c9bec3cb30a6fa2339bf42a591566a12b77c82df48b0bf6105a7a5c7b944e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anemia</topic><topic>Angiogenesis</topic><topic>Antigens, CD - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silver, Karlee L</au><au>Conroy, Andrea L</au><au>Leke, Rose G F</au><au>Leke, Robert J I</au><au>Gwanmesia, Philomina</au><au>Molyneux, Malcolm E</au><au>Taylor, Diane Wallace</au><au>Wallace, Diane Taylor</au><au>Rogerson, Stephen J</au><au>Kain, Kevin C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-09-22</date><risdate>2011</risdate><volume>6</volume><issue>9</issue><spage>e24985</spage><epage>e24985</epage><pages>e24985-e24985</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Placental infections with Plasmodium falciparum are associated with fetal growth restriction resulting in low birth weight (LBW). The mechanisms that mediate these effects have yet to be completely described; however, they are likely to involve inflammatory processes and dysregulation of angiogenesis. Soluble endoglin (sEng), a soluble receptor of transforming growth factor (TGF)-β previously associated with preeclampsia in pregnant women and with severe malaria in children, regulates the immune system and influences angiogenesis. We hypothesized that sEng may play a role in development of LBW associated with placental malaria (PM). Plasma levels of sEng were measured in women (i) followed prospectively throughout pregnancy in Cameroon (n = 52), and (ii) in a case-control study at delivery in Malawi (n = 479). The relationships between sEng levels and gravidity, peripheral and placental parasitemia, gestational age, and adverse outcomes of PM including maternal anemia and LBW were determined. In the longitudinal cohort from Cameroon, 28 of 52 women (54%) experienced at least one malaria infection during pregnancy. In Malawi we enrolled two aparasitemic gravidity-matched controls for every case with PM. sEng levels varied over the course of gestation and were significantly higher in early and late gestation as compared to delivery (P<0.006 and P<0.0001, respectively). Circulating sEng levels were higher in primigravidae than multigravidae from both Cameroon and Malawi, irrespective of malarial infection status (p<0.046 and p<0.001, respectively). Peripheral parasitemia in Cameroonian women and PM in Malawian women were each associated with elevated sEng levels following correction for gestational age and gravidity (p = 0.006 and p = 0.033, respectively). Increased sEng was also associated with the delivery of LBW infants in primigravid Malawian women (p = 0.017); the association was with fetal growth restriction (p = 0.003) but not pre-term delivery (p = 0.286). Increased circulating maternal sEng levels are associated with P. falciparum infection in pregnancy and with fetal growth restriction in primigravidae with PM.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21966395</pmid><doi>10.1371/journal.pone.0024985</doi><tpages>e24985</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-09, Vol.6 (9), p.e24985-e24985 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1308930631 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Anemia Angiogenesis Antigens, CD - blood Biology Biomedical research Birth control Birth weight Cameroon Case-Control Studies Children Chondroitin sulfate Consent Endoglin Ethics Female Fetal development Fetal Growth Retardation - blood Fetuses Gestation Gestational Age Growth Health aspects Health care networks Hospitals Humans Immune system Infants Infection Infections Inflammation Laboratories Low birth weight Malaria Malaria - blood Malawi Medicine Neovascularization, Physiologic Parasitemia Parasites Placenta Placenta - parasitology Plasma levels Plasmodium falciparum Pre-eclampsia Preeclampsia Pregnancy Pregnancy Complications, Parasitic Pregnancy Outcome Pregnant women Prospective Studies Receptors, Cell Surface - blood Sexual behavior Stem cells Studies Syphilis Transforming Growth Factor beta - metabolism Transforming growth factor-a Transforming growth factors Tropical diseases Ultrasonic imaging Vector-borne diseases Womens health |
| title | Circulating soluble endoglin levels in pregnant women in Cameroon and Malawi--associations with placental malaria and fetal growth restriction |
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