Early hypothalamic FTO overexpression in response to maternal obesity--potential contribution to postweaning hyperphagia

Intrauterine and postnatal overnutrition program hyperphagia, adiposity and glucose intolerance in offspring. Single-nucleotide polymorphisms (SNPs) of the fat mass and obesity associated (FTO) gene have been linked to increased risk of obesity. FTO is highly expressed in hypothalamic regions critic...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25261-e25261
Hauptverfasser:	Caruso, Vanni, Chen, Hui, Morris, Margaret J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipose tissue Alpha-Ketoglutarate-Dependent Dioxygenase FTO Animals Biology Body fat Body weight Brain Breastfeeding & lactation Carnitine Carnitine palmitoyltransferase Correlation Diabetes Diet, High-Fat - adverse effects Energy Energy balance Fatty acid synthesis Fatty acids Fatty-acid synthase Feeding Female Fetal development Fetuses Food intake Gene expression Genes Genetic aspects Gestation Glucose Glucose tolerance High fat diet Homeostasis Hyperphagia Hypothalamus Hypothalamus - metabolism Intolerance Lactation Lipid metabolism Liver Liver - metabolism Male Markers Mating Medicine Metabolism Nutrition Obesity Obesity - etiology Obesity - metabolism Offspring Overnutrition Pharmacology Physiological aspects Proteins Proteins - genetics Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction RNA RNA, Messenger - genetics Rodents Siblings Single nucleotide polymorphisms Studies Transcription factors Transgenic animals Type 2 diabetes Weaning Weight reduction
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