ProteinSeq: high-performance proteomic analyses by proximity ligation and next generation sequencing

Despite intense interest, methods that provide enhanced sensitivity and specificity in parallel measurements of candidate protein biomarkers in numerous samples have been lacking. We present herein a multiplex proximity ligation assay with readout via realtime PCR or DNA sequencing (ProteinSeq). We...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25583-e25583
Hauptverfasser:	Darmanis, Spyros, Nong, Rachel Yuan, Vänelid, Johan, Siegbahn, Agneta, Ericsson, Olle, Fredriksson, Simon, Bäcklin, Christofer, Gut, Marta, Heath, Simon, Gut, Ivo Glynne, Wallentin, Lars, Gustafsson, Mats G, Kamali-Moghaddam, Masood, Landegren, Ulf
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Assaying Bioindicators Biology biomarker Biomarkers Biomarkers - blood Blood plasma Blood Proteins - analysis Blood Proteins - genetics Cardiovascular disease Cardiovascular diseases Comparative analysis Coronary vessels Cystatin Cystatins Deoxyribonucleic acid Diagnostic systems Disease control DNA DNA sequencing Gene sequencing Growth factors Heart attacks Humans Immunoassay - economics Immunoassay - methods Immunoglobulins Immunology Informatics Kallikrein Laboratories Medicine Methods Molecular Medicine Molecular weight Molekylär medicin Multiplexing Multivariate Analysis next generation sequencing P-selectin Pathology Physics Prostate cancer Proteins Proteomics Proteomics - economics Proteomics - methods proximity ligation assay Science Sensitivity Sensitivity analysis Sensitivity enhancement Sequence Analysis, DNA - economics Sequence Analysis, DNA - methods Studies Time Factors
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