Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway

Memory formation is modulated by pre- and post-synaptic signaling events in neurons. The neuronal protein kinase Cyclin-Dependent Kinase 5 (Cdk5) phosphorylates a variety of synaptic substrates and is implicated in memory formation. It has also been shown to play a role in homeostatic regulation of...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25735-e25735
Hauptverfasser:	Guan, Ji-Song, Su, Susan C, Gao, Jun, Joseph, Nadine, Xie, Zhigang, Zhou, Ying, Durak, Omer, Zhang, Lei, Zhu, J Julius, Clauser, Karl R, Carr, Steven A, Tsai, Li-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Animals Biology Blotting, Southern Brain research Cell cycle Cyclic adenosine monophosphate Cyclic AMP - metabolism Cyclic AMP response element-binding protein Cyclin-dependent kinase 5 Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism Cyclin-dependent kinases Electrophysiology Hippocampal plasticity Hippocampus Hippocampus - metabolism Homeostatic plasticity Immunoblotting Immunohistochemistry Inhibitors Kinases Mass spectrometry Maze Learning Medicine Memory Memory - physiology Mice Mice, Inbred C57BL Mice, Mutant Strains Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurons Phosphodiesterase Phosphorylation Plasticity Protein kinase Protein kinase C Protein kinases Proteins Reverse Transcriptase Polymerase Chain Reaction Rodents Rolipram Scientific imaging Signal transduction Signal Transduction - genetics Signal Transduction - physiology Signaling Social and Behavioral Sciences Substrates Synaptic plasticity
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