Enhanced pro-inflammatory cytokine responses following Toll-like-receptor ligation in Schistosoma haematobium-infected schoolchildren from rural Gabon

Schistosoma infection is thought to lead to down-regulation of the host's immune response. This has been shown for adaptive immune responses, but the effect on innate immunity, that initiates and shapes the adaptive response, has not been extensively studied. In a first study to characterize th...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24393-e24393
Hauptverfasser:	Meurs, Lynn, Labuda, Lucja, Amoah, Abena Serwaa, Mbow, Moustapha, Ngoa, Ulysse Ateba, Boakye, Daniel Adjei, Mboup, Souleymane, Dièye, Tandakha Ndiaye, Mountford, Adrian P, Turner, Joseph D, Kremsner, Peter Gottfried, Polman, Katja, Yazdanbakhsh, Maria, Adegnika, Ayola Akim
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adolescent Animals Antigens Biology Cell culture Cells, Cultured Chemotherapy Child Children Cytokines Cytokines - biosynthesis Cytokines - blood Cytokines - immunology Dendritic cells Down-regulation Eggs Elementary school students Female Health aspects Hospitals Humans Hypotheses Immune response Immune system Immunity Immunology Incubation Infections Inflammation Inflammation Mediators - immunology Innate immunity Interleukin 10 Laboratories Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - parasitology Ligands Lipopolysaccharides Malaria Male Medical research Medicine Parasites Parasitic diseases Parasitology Peripheral blood mononuclear cells Poly (I:C) Proteins Rural areas Rural Population Schistosoma Schistosoma haematobium Schistosoma haematobium - immunology Schistosoma mansoni Schistosomiasis haematobia - immunology Schistosomiasis haematobia - parasitology Schools Staphylococcus aureus Tetanus TLR2 protein TLR3 protein TLR4 protein Toll-like receptors Toll-Like Receptors - immunology Tropical diseases Tuberculosis Tumor necrosis factor-TNF Tumor necrosis factor-α Urine
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