Analysis of hypoxia and hypoxia-like states through metabolite profiling

In diverse organisms, adaptation to low oxygen (hypoxia) is mediated through complex gene expression changes that can, in part, be mimicked by exposure to metals such as cobalt. Although much is known about the transcriptional response to hypoxia and cobalt, little is known about the all-important c...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24741
Hauptverfasser:	Gleason, Julie E, Corrigan, David J, Cox, James E, Reddi, Amit R, McGinnis, Lauren A, Culotta, Valeria C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Adaptations Amino acids Analysis Aromatic compounds Aromatics Baking yeast Biochemistry Biology Biosynthesis Cell Hypoxia - drug effects Cell Hypoxia - physiology Chromatography Chromatography, Gas Cobalt Cobalt - pharmacology Cytosol Dehydration Desaturation Environmental stress Enzymatic activity Enzymes Exposure Fatty acids Fatty Acids - metabolism Gas Chromatography-Mass Spectrometry Gene expression Genes Genetics Heavy metals Heme Homeostasis Homology Hypoxia Immunoblotting Iron Iron proteins Laboratories Leucine Low molecular weights Metabolism Metabolites Methionine Mitochondria Molecular biology Molecular weight Oxygen Physiological aspects Physiology Profiling Protein expression Proteins Public health Ribonucleotide reductase Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - metabolism Sterols Sterols - metabolism Transcription Transcription factors Unsaturated fatty acids Yeast Yeasts
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