Clodronate liposomes improve metabolic profile and reduce visceral adipose macrophage content in diet-induced obese mice

Obesity-related adipose inflammation has been thought to be a causal factor for the development of insulin resistance and type 2 diabetes. Infiltrated macrophages in adipose tissue of obese animals and humans are an important source for inflammatory cytokines. Clodronate liposomes can ablate macroph...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24358-e24358
Hauptverfasser:	Feng, Bin, Jiao, Ping, Nie, Yaohui, Kim, Thomas, Jun, Dale, van Rooijen, Nico, Yang, Zaiqing, Xu, Haiyan
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Adipocytes - pathology Adipokines - blood Adiponectin Adipose tissue Adipose Tissue - pathology Animals Apoptosis B cells Biology Bisphosphonates Blood glucose Blood Glucose - drug effects Blood Glucose - metabolism Body Weight - drug effects Bone disorder agents Clodronic acid Clodronic Acid - pharmacology Clodronic Acid - therapeutic use Coculture Techniques Cytokines Diabetes mellitus Diet Fatty Liver - drug therapy Fatty Liver - pathology Glucose Glucose tolerance Glucose Tolerance Test Histology Homeostasis Humans Inflammation Injection Insulin Insulin - blood Insulin - pharmacology Insulin resistance Kinases Liposomes Liposomes - chemistry Liver Liver - drug effects Liver - metabolism Liver - pathology Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Male Medicine Metabolome - drug effects Mice Mice, Inbred C57BL Mice, Obese Molecular weight Mouse devices Obesity Organ Size - drug effects Peritoneum Rodents Sensitivity Sensitivity analysis Sensitizing Stromal Cells - drug effects Stromal Cells - metabolism Stromal Cells - pathology Triglycerides - metabolism Tumor necrosis factor-TNF Type 2 diabetes Viscera - pathology
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