Modulation of catalytic activity in multi-domain protein tyrosine phosphatases

Signaling mechanisms involving protein tyrosine phosphatases govern several cellular and developmental processes. These enzymes are regulated by several mechanisms which include variation in the catalytic turnover rate based on redox stimuli, subcellular localization or protein-protein interactions....

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24766-e24766
Hauptverfasser:	Madan, Lalima L, Veeranna, S, Shameer, Khader, Reddy, Chilamakuri C S, Sowdhamini, R, Gopal, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biology Biophysics Catalysis Catalytic activity Chromosomes - genetics Computer simulation Drosophila Drosophila melanogaster Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Enzymes Gene expression Insects Kinases Leukocytes Localization Molecular dynamics Molecular Dynamics Simulation Peptides Phenols (Class of compounds) Phosphatase Phosphatases Protein interaction Protein Structure, Tertiary - genetics Protein Tyrosine Phosphatases - chemistry Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Protein-protein interactions Protein-tyrosine-phosphatase Proteins Science Signaling Structural models Studies Substrate Specificity Turnover rate Tyrosine
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