Lumican expression in diaphragm induced by mechanical ventilation

Diaphragmatic dysfunction found in the patients with acute lung injury required prolonged mechanical ventilation. Mechanical ventilation can induce production of inflammatory cytokines and excess deposition of extracellular matrix proteins via up-regulation of transforming growth factor (TGF)-β1. Lu...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24692-e24692
Hauptverfasser:	Li, Li-Fu, Chen, Bao-Xiang, Tsai, Ying-Huang, Kao, Winston W-Y, Yang, Cheng-Ta, Chu, Pao-Hsien
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Activation Animals Biology Bone morphogenetic proteins Chemokines Chondroitin Sulfate Proteoglycans - metabolism Collagen Collagen (type I) Collagen - metabolism Cornea Critical care Cytokines Diaphragm Diaphragm (anatomy) Diaphragm - metabolism Dismantling Extracellular matrix Fibronectin Fibronectins Fibronectins - metabolism Gene Expression Regulation Hospitals House mouse Inflammation Injuries Internal medicine Keratan Sulfate - metabolism Lumican Lung diseases Lungs Male Mechanical ventilation Medicine Mice Mice, Inbred C57BL mRNA Muscle proteins Neutrophils Procollagen Procollagen - metabolism Proteins Pulmonary fibrosis Respiration, Artificial - adverse effects Respiratory distress syndrome Respiratory therapy RNA Rodents Signaling Smooth muscle Tidal Volume - physiology Transforming growth factor Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Transforming growth factors Vascular endothelial growth factor Ventilation Ventilators Working groups Wound healing
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