Angiopoietin-like 4 regulates epidermal differentiation

The nuclear hormone receptor PPARβ/δ is integral to efficient wound re-epithelialization and implicated in epidermal maturation. However, the mechanism underlying the latter process of epidermal differentiation remains unclear. We showed that ligand-activated PPARβ/δ indirectly stimulated keratinocy...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25377-e25377
Hauptverfasser:	Pal, Mintu, Tan, Ming Jie, Huang, Royston-Luke, Goh, Yan Yih, Wang, Xiao Ling, Tang, Mark Boon Yang, Tan, Nguan Soon
Format:	Artikel
Sprache:	eng
Schlagworte:	Activator protein 1 Adipocytes Angiogenesis Angiopoietin Angiopoietin-like 4 Protein Angiopoietins - genetics Angiopoietins - metabolism Animals Biology Biopsy c-Jun protein Cell adhesion & migration Cell Differentiation - drug effects Cell Differentiation - genetics Cell growth Cells, Cultured Chromatin Chromatin Immunoprecipitation Differentiation Down-regulation Epidermis - cytology Epidermis - metabolism Fasting Fibrinogen Fluorescent Antibody Technique Fluorides Gene expression Gene regulation Genes Genetic aspects Humans Immunoblotting Immunoglobulins Immunoprecipitation Isotypes JunB protein Keratinocytes Keratinocytes - cytology Keratinocytes - metabolism Keratinocytes - microbiology Kinases Ligands Liver cancer Maturation Medicine Metastasis Mice Mice, Knockout Monoclonal antibodies PPAR delta - agonists PPAR delta - metabolism PPAR-beta - agonists PPAR-beta - metabolism Promoter Regions, Genetic - genetics Protein Binding - drug effects Protein Binding - genetics Protein kinase C Protein kinases Protein Precursors - genetics Proteins Real-Time Polymerase Chain Reaction Rodents Science Signal transduction Signaling Skin Smooth muscle Thiazoles - pharmacology Transcription (Genetics) Transcription factors Transglutaminases - genetics Translation (Genetics) Wound healing Wounds
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