Combining antigen-based therapy with GABA treatment synergistically prolongs survival of transplanted ß-cells in diabetic NOD mice

Antigen-based therapies (ABTs) very effectively prevent the development of type 1 diabetes (T1D) when given to young nonobese diabetic (NOD) mice, however, they have little or no ability to reverse hyperglycemia in newly diabetic NOD mice. More importantly, ABTs have not yet demonstrated an ability...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25337-e25337
Hauptverfasser:	Tian, Jide, Dang, Hoa, Kaufman, Daniel L
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alum Aluminum sulfate Animal models Animals Antigens Arthritis Autoimmune diseases B cells Biology Cell survival Chloride Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - prevention & control Diabetes Mellitus, Type 1 - therapy Diabetes therapy Drinking water Experimental allergic encephalomyelitis Female GABA gamma-Aminobutyric Acid - therapeutic use Glucose Glutamate decarboxylase Glutamate Decarboxylase - therapeutic use Grafts Health aspects Humans Hyperglycemia Hyperglycemia - drug therapy Hyperglycemia - therapy Immune system Immunotherapy Insulin Islets of Langerhans Transplantation Lymphocytes Lymphocytes T Medicine Mice Mice, Inbred NOD Nervous system Pancreas Pharmacology Receptors Regulation Rheumatoid arthritis Rheumatoid factor Rodents Survival Synergistic effect T cells Transplantation Transplants & implants Type 1 diabetes
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