Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala

Protein degradation through the ubiquitin-proteasome system [UPS] plays a critical role in some forms of synaptic plasticity. However, its role in memory formation in the amygdala, a site critical for the formation of fear memories, currently remains unknown. Here we provide the first evidence that...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24349
Hauptverfasser:	Jarome, Timothy J, Werner, Craig T, Kwapis, Janine L, Helmstetter, Fred J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - drug effects Amygdala - metabolism Amygdala - physiology Animal behavior Animal memory Animals Biodegradation Biology Conditioning, Psychological - physiology Cysteine Proteinase Inhibitors - pharmacology Degradation Delivery services DNA Helicases - metabolism Excitatory Amino Acid Antagonists - pharmacology Fear Fear - physiology Fear conditioning Gene expression Immunoblotting Lactones - pharmacology Long term memory Male Memory - physiology Memory, Long-Term - physiology N-Methyl-D-aspartic acid N-Methylaspartate - metabolism Neuronal Plasticity - physiology Neurons Neurophysiology Neurosciences Piperidines - pharmacology Plasticity Proteasome Endopeptidase Complex - metabolism Proteasomes Protein synthesis Proteins Proteolysis Proteolysis - drug effects Rats Rats, Long-Evans Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Retrieval Rodents Social and Behavioral Sciences Stability Studies Synapses Synapses - metabolism Synapses - physiology Synaptic plasticity Synaptogenesis Time Factors Translation Ubiquitin Ubiquitin - metabolism Ubiquitination - drug effects
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