A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast
Metabolic gene clusters--functionally related and physically clustered genes--are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothe...
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| Veröffentlicht in: | PloS one 2011-09, Vol.6 (9), p.e25290-e25290 |
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| description | Metabolic gene clusters--functionally related and physically clustered genes--are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of GAL genes in the yeast genome. We find that, although clustering coordinates the expression of GAL1 and GAL10, disrupting the GAL cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters. |
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Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of GAL genes in the yeast genome. We find that, although clustering coordinates the expression of GAL1 and GAL10, disrupting the GAL cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0025290</identifier><identifier>PMID: 21966486</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Ascomycota ; Aspergillus ; Baking yeast ; Biology ; Cellular biology ; Clustering ; Clusters ; Enzymes ; Fitness ; Fungi ; Galactokinase - genetics ; Galactose ; Gene clusters ; Gene expression ; Genes ; Genomes ; Genomics ; Glucose ; Hypotheses ; Maintenance ; Metabolism ; Metabolites ; Multigene Family - genetics ; Population genetics ; Reproductive fitness ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae Proteins - genetics ; Saccharomyces paradoxus ; Standard deviation ; Trans-Activators - genetics ; Yeast ; Yeasts</subject><ispartof>PloS one, 2011-09, Vol.6 (9), p.e25290-e25290</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Lang, Botstein. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Lang, Botstein. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-c712c748f270c9a6090795c73b45cb459425dda465d1876cb77478eb03c5de543</citedby><cites>FETCH-LOGICAL-c691t-c712c748f270c9a6090795c73b45cb459425dda465d1876cb77478eb03c5de543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178652/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178652/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21966486$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rusche, Laura N.</contributor><creatorcontrib>Lang, Gregory I</creatorcontrib><creatorcontrib>Botstein, David</creatorcontrib><title>A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Metabolic gene clusters--functionally related and physically clustered genes--are a common feature of some eukaryotic genomes. Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of GAL genes in the yeast genome. We find that, although clustering coordinates the expression of GAL1 and GAL10, disrupting the GAL cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters.</description><subject>Ascomycota</subject><subject>Aspergillus</subject><subject>Baking yeast</subject><subject>Biology</subject><subject>Cellular biology</subject><subject>Clustering</subject><subject>Clusters</subject><subject>Enzymes</subject><subject>Fitness</subject><subject>Fungi</subject><subject>Galactokinase - genetics</subject><subject>Galactose</subject><subject>Gene clusters</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Glucose</subject><subject>Hypotheses</subject><subject>Maintenance</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Multigene Family - genetics</subject><subject>Population genetics</subject><subject>Reproductive fitness</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae Proteins - genetics</subject><subject>Saccharomyces paradoxus</subject><subject>Standard deviation</subject><subject>Trans-Activators - genetics</subject><subject>Yeast</subject><subject>Yeasts</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk9-LGyEQx5fS0rte-x-UdqHQ0oek6rq6vhTC0V4DgYP-ehVXZxPDRnPqlst_X3PZHJdyD0VEmfnMd3R0iuI1RlNccfxp7YfgVD_degdThEhNBHpSnGNRkQkjqHr6YH9WvIhxjVBdNYw9L84IFozRhp0X61mZIKbSd2VaQam9D8Y6lcCUcLsNEKP1rlzttj67o41l58Md6YNdWlcqZ8qNsi6BU07DUedqtih1P8QEoczUDlRML4tnneojvBrXi-LX1y8_L79NFtdX88vZYqKZwGmiOSaa06YjHGmhGBKIi1rzqqW1zlNQUhujKKsNbjjTLeeUN9CiStcGalpdFG8PutveRzmWKUpcoYbWDFGUifmBMF6t5TbYjQo76ZWVdwYfllKFZHUP0nAjTM6qKDDKVd1WbdsRilWroBNQZa3PY7ah3YDR4FJQ_YnoqcfZlVz6P7LCvGE1yQIfRoHgb4b8FnJjo4a-Vw78EGUjGKGoISKT7_4hH7_cSC1VPr91nc9p9V5TzihnDedC7KnpI1QeBjZW5y_V2Ww_Cfh4EpCZBLdpqYYY5fzH9_9nr3-fsu8fsCtQfVpF3w8p_7t4CtIDqIOPMUB3X2OM5L4jjtWQ-46QY0fksDcP3-c-6NgC1V_GiQaH</recordid><startdate>20110922</startdate><enddate>20110922</enddate><creator>Lang, Gregory I</creator><creator>Botstein, David</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110922</creationdate><title>A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast</title><author>Lang, Gregory I ; Botstein, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-c712c748f270c9a6090795c73b45cb459425dda465d1876cb77478eb03c5de543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Ascomycota</topic><topic>Aspergillus</topic><topic>Baking yeast</topic><topic>Biology</topic><topic>Cellular biology</topic><topic>Clustering</topic><topic>Clusters</topic><topic>Enzymes</topic><topic>Fitness</topic><topic>Fungi</topic><topic>Galactokinase - 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Two hypotheses have been advanced to explain the origin and maintenance of metabolic gene clusters: coordinated gene expression and genetic linkage. Here we test the hypothesis that selection for coordinated gene expression underlies the clustering of GAL genes in the yeast genome. We find that, although clustering coordinates the expression of GAL1 and GAL10, disrupting the GAL cluster does not impair fitness, suggesting that other mechanisms, such as genetic linkage, drive the origin and maintenance metabolic gene clusters.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21966486</pmid><doi>10.1371/journal.pone.0025290</doi><tpages>e25290</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Ascomycota Aspergillus Baking yeast Biology Cellular biology Clustering Clusters Enzymes Fitness Fungi Galactokinase - genetics Galactose Gene clusters Gene expression Genes Genomes Genomics Glucose Hypotheses Maintenance Metabolism Metabolites Multigene Family - genetics Population genetics Reproductive fitness Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces paradoxus Standard deviation Trans-Activators - genetics Yeast Yeasts |
| title | A test of the coordinated expression hypothesis for the origin and maintenance of the GAL cluster in yeast |
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