Novel aptamer-nanoparticle bioconjugates enhances delivery of anticancer drug to MUC1-positive cancer cells in vitro

MUC1 protein is an attractive target for anticancer drug delivery owing to its overexpression in most adenocarcinomas. In this study, a reported MUC1 protein aptamer is exploited as the targeting agent of a nanoparticle-based drug delivery system. Paclitaxel (PTX) loaded poly (lactic-co-glycolic-aci...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24077
Hauptverfasser:	Yu, Chenchen, Hu, Yan, Duan, Jinhong, Yuan, Wei, Wang, Chen, Xu, Haiyan, Yang, Xian-Da
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Analysis Antineoplastic Agents - metabolism Antitumor agents Aptamers Aptamers, Nucleotide - chemistry Aptamers, Nucleotide - genetics Aptamers, Nucleotide - metabolism Base Sequence Biological Transport Biology Breast cancer Cancer Cancer cells Cancer therapies Cell Line, Tumor Cytometry Cytotoxicity Deoxyribonucleic acid DNA Drug Carriers - chemistry Drug Carriers - metabolism Drug delivery Drug delivery systems Drug therapy Evaporation Flow cytometry Hep G2 Cells Humans Medicine Mucin-1 - metabolism Mucins Nanoparticles Nanoparticles - chemistry Ovarian cancer Paclitaxel Paclitaxel - metabolism Polylactide-co-glycolide Prostate cancer Spacer Toxicity Tumors
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