Endothelial induced EMT in breast epithelial cells with stem cell properties

Epithelial to mesenchymal transition (EMT) is a critical event in cancer progression and is closely linked to the breast epithelial cancer stem cell phenotype. Given the close interaction between the vascular endothelium and cancer cells, especially at the invasive front, we asked whether endothelia...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e23833-e23833
Hauptverfasser:	Sigurdsson, Valgardur, Hilmarsdottir, Bylgja, Sigmundsdottir, Hekla, Fridriksdottir, Agla J R, Ringnér, Markus, Villadsen, Rene, Borg, Ake, Agnarsson, Bjarni A, Petersen, Ole William, Magnusson, Magnus K, Gudjonsson, Thorarinn
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Apoptosis Apoptosis - physiology Biology Blotting, Western Breast cancer Cancer Cancer and Oncology Cancer och onkologi Cell culture Cell Dedifferentiation Cell Line Cell Line, Tumor Cells, Cultured Clinical Medicine E-cadherin Endothelial cells Endothelium Epidermal growth factor Epidermal Growth Factor - metabolism Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial-Mesenchymal Transition Female Fibroblast Growth Factors - metabolism Fibroblasts Flow Cytometry Genotype & phenotype Health sciences Hematology Hepatocyte Growth Factor - metabolism Hospitals Humans Hypoxia Immunochemistry In Vitro Techniques Invasiveness Keratin Klinisk medicin Laboratories Liver cancer Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicine Mesenchyme Metastasis Morphogenesis N-Cadherin Neoplastic Stem Cells - cytology Neoplastic Stem Cells - metabolism Properties (attributes) Rodents Signaling Stem cells Three dimensional models Transforming Growth Factor beta1 - metabolism Tumors Vascular endothelial growth factor
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