Bothrops jararaca peptide with anti-hypertensive action normalizes endothelium dysfunction involved in physiopathology of preeclampsia

Preeclampsia, a pregnancy-specific syndrome characterized by hypertension, proteinuria and edema, is a major cause of fetal and maternal morbidity and mortality especially in developing countries. Bj-PRO-10c, a proline-rich peptide isolated from Bothrops jararaca venom, has been attributed with pote...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e23680
Hauptverfasser:	Benedetti, Gabriel, Morais, Katia L P, Guerreiro, Juliano R, de Oliveira, Eduardo Fontana, Hoshida, Mara Sandra, Oliveira, Leandro, Sass, Nelson, Lebrun, Ivo, Ulrich, Henning, Lameu, Claudiana, de Camargo, Antonio Carlos Martins
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antihypertensive agents Antihypertensive Agents - pharmacology Antihypertensives Arginine - metabolism Argininosuccinate synthase Argininosuccinate Synthase - metabolism Biological effects Biology Blood pressure Blotting, Western Bothrops - metabolism Bothrops jararaca Calcium Calcium (intracellular) Calcium - metabolism Cells, Cultured Citrulline Citrulline - metabolism Coronary vessels Developing countries Dose-Response Relationship, Drug Drug development Edema Endothelial cells Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Enzymes Female Fetuses Fluxes Heart rate Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hypertension LDCs Medicine Morbidity Mortality Neutrophils Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Oligopeptides - pharmacology Peptides Pre-eclampsia Pre-Eclampsia - pathology Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Pregnancy Complications, Cardiovascular - pathology Pregnancy Complications, Cardiovascular - physiopathology Pregnant women Proline Proteins Proteinuria Rats Rodents Smooth muscle Superoxide Superoxides Superoxides - metabolism Umbilical vein Venom Viper Venoms - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!