P2X7 receptor and caspase 1 activation are central to airway inflammation observed after exposure to tobacco smoke

Chronic Obstructive Pulmonary Disease (COPD) is a cigarette smoke (CS)-driven inflammatory airway disease with an increasing global prevalence. Currently there is no effective medication to stop the relentless progression of this disease. It has recently been shown that an activator of the P2X7/infl...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e24097
Hauptverfasser:	Eltom, Suffwan, Stevenson, Christopher S, Rastrick, Joseph, Dale, Nicole, Raemdonck, Kristof, Wong, Sissie, Catley, Matthew C, Belvisi, Maria G, Birrell, Mark A
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosine Animals Biology Caspase Caspase 1 - metabolism Caspase-1 Cell activation Chronic exposure Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Conditioned stimulus Cytokines Development and progression Developmental stages Drugs Emphysema Exposure Genetic modification Genetically modified organisms Heart Humans Hypotheses In Vitro Techniques Inflammasomes Inflammation Inflammation - chemically induced Inflammation - metabolism Interleukin 18 Interleukin-18 - metabolism Interleukin-1beta - metabolism Laboratories Lipopolysaccharides - toxicity Lung diseases Lungs Male Medical research Medicine Mice Neutrophilia Neutrophils Obstructive lung disease Pathogenesis Patients Pharmacology Physiology Receptors Receptors, Purinergic P2X7 - metabolism Respiratory System - drug effects Respiratory System - metabolism Respiratory tract diseases Rodents Smoke Smoking Smoking - adverse effects Tobacco Tobacco smoke Tumor necrosis factor-TNF
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