Effect of D222G mutation in the hemagglutinin protein on receptor binding, pathogenesis and transmissibility of the 2009 pandemic H1N1 influenza virus

Influenza viruses isolated during the 2009 H1N1 pandemic generally lack known molecular determinants of virulence associated with previous pandemic and highly pathogenic avian influenza viruses. The frequency of the amino acid substitution D222G in the hemagglutinin (HA) of 2009 H1N1 viruses isolate...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e25091-e25091
Hauptverfasser:	Belser, Jessica A, Jayaraman, Akila, Raman, Rahul, Pappas, Claudia, Zeng, Hui, Cox, Nancy J, Katz, Jacqueline M, Sasisekharan, Ram, Tumpey, Terrence M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid substitution Amino acids Analysis Animals Avian flu Avian influenza Avian influenza viruses Avidity Binding Biology Cell Line Cells (Biology) Disease transmission Epithelial cells Female Ferrets Genetic aspects Genetics Glycan Hemagglutinins Hemagglutinins - genetics Hemagglutinins - metabolism Humans Immunization Influenza Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - metabolism Influenza A Virus, H1N1 Subtype - pathogenicity Influenza, Human - transmission Influenza, Human - virology Kinetics Lectins Lethargy Male Medical research Medicine Mice Mice, Inbred BALB C Mutation Pandemics Pathogenesis Protein binding Receptors Replication Respiratory tract Swine influenza Tropism Vaccines Virulence Virulence (Microbiology) Viruses Weight loss
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