The 4C5 cell-impermeable anti-HSP90 antibody with anti-cancer activity, is composed of a single light chain dimer

MAb 4C5 is a cell impermeable, anti-HSP90 murine monoclonal antibody, originally produced using hybridoma technology. We have previously shown that mAb 4C5 specifically recognizes both the α- and to a lesser extent the β-isoform of HSP90. Additionally, in vitro and in vivo studies revealed that by s...

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Veröffentlicht in:	PloS one 2011-09, Vol.6 (9), p.e23906-e23906
Hauptverfasser:	Sidera, Katerina, El Hamidieh, Avraam, Mamalaki, Avgi, Patsavoudi, Evangelia
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - genetics Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Antibody Specificity Anticancer properties Antigens Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Bands Base Sequence Biochemistry Biology Breast cancer Cancer Cancer metastasis Cancer treatment Cell Line, Tumor Cell surface Chains Cloning Cloning, Molecular E coli Female Heat shock proteins HSP90 Heat-Shock Proteins - immunology Hsp90 protein Humans Hybridomas - cytology Immunogenicity Immunoglobulin kappa-Chains - chemistry Immunoglobulin kappa-Chains - genetics Immunoglobulin kappa-Chains - metabolism Immunoglobulin kappa-Chains - pharmacology Immunoglobulins In vivo methods and tests Laboratories Light Localization Lung - drug effects Lung - pathology Lung cancer Lungs Medicine Metastases Metastasis Mice Molecular Sequence Data Monoclonal antibodies Motility Neoplasm Invasiveness Neoplasm Metastasis Permeability Protein Multimerization Protein Structure, Quaternary Proteins Sequence Analysis, DNA Single-Chain Antibodies - chemistry Single-Chain Antibodies - genetics Single-Chain Antibodies - metabolism Single-Chain Antibodies - pharmacology Tumorigenesis
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