Apelin deficiency accelerates the progression of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the selective loss of motor neurons. Recent studies have implicated that chronic hypoxia and insufficient vascular endothelial growth factor (VEGF)-dependent neuroprotection may lead to the degeneration of motor neur...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e23968
Hauptverfasser:	Kasai, Atsushi, Kinjo, Toshihiko, Ishihara, Rie, Sakai, Ikumi, Ishimaru, Yuki, Yoshioka, Yasuhiro, Yamamuro, Akiko, Ishige, Kumiko, Ito, Yoshihisa, Maeda, Sadaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - pathology Analysis Angiogenesis Animal tissues Animals Apelin Biology Central nervous system Degeneration Development and progression Disease Progression Drug therapy Excitotoxicity Gene expression Glutamate HIV Human immunodeficiency virus Hydrogen peroxide Hypoxia Immunoreactivity Intercellular Signaling Peptides and Proteins - analysis Intercellular Signaling Peptides and Proteins - deficiency Intercellular Signaling Peptides and Proteins - genetics Laboratories Medicine Mice Microglia Motor neurone disease Motor neurons Motor Neurons - pathology Mutation Nervous system diseases Neurodegeneration Neurons Neuroprotection Neuroprotective Agents Neurotoxicity Nitric oxide Pathogenesis Pharmaceutical sciences Pharmacy Phenotypes Proteins RNA RNA, Messenger - analysis Rodents Spinal cord Spinal Cord - chemistry Substantia grisea Tetanus Tissue Distribution Vascular endothelial growth factor
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