Curcumin-loaded apotransferrin nanoparticles provide efficient cellular uptake and effectively inhibit HIV-1 replication in vitro

Curcumin (diferuloylmethane) shows significant activity across a wide spectrum of conditions, but its usefulness is rather limited because of its low bioavailability. Use of nanoparticle formulations to enhance curcumin bioavailability is an emerging area of research. In the present study, curcumin-...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e23388
Hauptverfasser:	Gandapu, Upendhar, Chaitanya, R K, Kishore, Golla, Reddy, Raju C, Kondapi, Anand K
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antigens, Neoplasm - metabolism Antiviral activity Apoproteins - metabolism Apotransferrin Atomic force microscopy Bioavailability Biochemistry Biology Biotechnology Cell Death - drug effects Cell Line Curcumin Curcumin - administration & dosage Curcumin - pharmacology Cyclooxygenase-2 Deoxyribonucleic acid DNA DNA topoisomerase (ATP-hydrolysing) DNA Topoisomerases, Type II - metabolism DNA, Viral - biosynthesis DNA-Binding Proteins - metabolism Drug Delivery Systems Drug dosages Endocytosis Enzymes Formulations Gene expression HIV HIV-1 - drug effects HIV-1 - physiology Human immunodeficiency virus Humans IL-1β Inflammation Inflammation - pathology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - metabolism Life sciences Lymphocytes Lymphocytes T Materials Science Medicine Microscopy Nanoparticles Nanoparticles - chemistry Nanotechnology Neutralization Tests Particle Size Receptors, Transferrin - metabolism Replication Synthesis T cells Transferrin Transferrin - metabolism Transferrins Tumor necrosis factor Ultraviolet radiation Virus replication Virus Replication - drug effects
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