Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression

Human embryonic and induced pluripotent stem cells (hESCs/hiPSCs) are promising cell sources for cardiac regenerative medicine. To realize hESC/hiPSC-based cardiac cell therapy, efficient induction, purification, and transplantation methods for cardiomyocytes are required. Though marker gene transdu...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e23657-e23657
Hauptverfasser:	Uosaki, Hideki, Fukushima, Hiroyuki, Takeuchi, Ayako, Matsuoka, Satoshi, Nakatsuji, Norio, Yamanaka, Shinya, Yamashita, Jun K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Biology Biomarkers - metabolism Bone marrow Calcium-binding protein Cardiomyocytes Cell adhesion Cell adhesion & migration Cell adhesion molecules Cell culture Cell growth Cell Line Cell Membrane - metabolism Cell Separation - methods Cell surface Differentiation Drug resistance Embryo cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryos Endothelium Fibroblasts Fluorescence Genetic modification Genetically modified organisms Growth factors Heart cells Heart diseases Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Laboratories Medical research Methods Monomolecular films Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Pericytes Pluripotency Purification R&D Regenerative medicine Research & development Stem cells Surface markers Therapy Transplantation Troponin Vascular cell adhesion molecule 1 Vascular Cell Adhesion Molecule-1 - metabolism
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