Large scale replication study of the association between HLA class II/BTNL2 variants and osteoarthritis of the knee in European-descent populations

Osteoarthritis (OA) is the most common form of arthritis and a major cause of disability. This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and deriving from a genome wide association scan (...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e23371
Hauptverfasser:	Valdes, Ana M, Styrkarsdottir, Unnur, Doherty, Michael, Morris, David L, Mangino, Massimo, Tamm, Agu, Doherty, Sally A, Kisand, Kalle, Kerna, Irina, Tamm, Ann, Wheeler, Margaret, Maciewicz, Rose A, Zhang, Weiya, Muir, Kenneth R, Dennison, Elaine M, Hart, Deborah J, Metrustry, Sarah, Jonsdottir, Ingileif, Jonsson, Gudbjorn F, Jonsson, Helgi, Ingvarsson, Thorvaldur, Cooper, Cyrus, Vyse, Timothy J, Spector, Tim D, Stefansson, Kari, Arden, Nigel K
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Arthritis Biocompatibility Biology Biomedical research Bone density Breast cancer Butyrophilins Case-Control Studies Chromosomes Clinical trials Comparative analysis Consortia Councils Descent Diabetes Disease DQA1 protein Drb1 protein Epidemiology Female Gene mapping Genetic aspects Genetic Loci - genetics Genetic Markers Genetic Predisposition to Disease Genetics Genetics, Population Genome-Wide Association Study Genomes Glaucoma Haplotypes Histocompatibility antigen HLA HLA antigens HLA-D Antigens - genetics Hospitals Humans Immunology Inflammation Inflammatory diseases Internal medicine Knee Leukocytes Linkage disequilibrium Linkage Disequilibrium - genetics Lymphocytes Male Medical research Medicine Membrane Glycoproteins - genetics Meta-Analysis as Topic Middle Aged Osteoarthritis Osteoarthritis, Knee - genetics Pathogenesis Polymorphism, Single Nucleotide - genetics Populations Reproducibility of Results Rheumatology Risk Single nucleotide polymorphisms Single-nucleotide polymorphism Studies White People - genetics
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