RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis

The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addre...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e22889
Hauptverfasser:	Ansari, Mairaj Ahmed, Zubair, Swaleha, Mahmood, Anjum, Gupta, Pushpa, Khan, Aijaz A, Gupta, Umesh D, Arora, Ashish, Owais, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Bacterial - immunology Bacillus Calmette-Guerin vaccine BCG Biology Biomarkers - metabolism Biotechnology Brucellosis Cell Proliferation Cloning Cytokines Cytokines - metabolism Cytotoxicity Delivery scheduling ESAT-6 antigen Flow Cytometry Genomes Humans Immunization Immunoglobulin G - immunology Immunologic Memory - immunology Immunological memory Immunology Infections Interdisciplinary aspects Laboratories Leishmania major Leukemia Lipids Lung - immunology Lung - microbiology Lung - pathology Lymphocytes Lymphocytes T Medical research Medicine Mice Mice, Inbred BALB C Mortality Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Nanoparticles - therapeutic use Proteins Schedules T cells Th1 Cells - cytology Th1 Cells - immunology Time Factors Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis - prevention & control Tuberculosis Vaccines - immunology Vaccines Virulence (Microbiology)
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