RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis
The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addre...
Gespeichert in:
| Veröffentlicht in: | PloS one 2011-08, Vol.6 (8), p.e22889 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 8 |
| container_start_page | e22889 |
| container_title | PloS one |
| container_volume | 6 |
| creator | Ansari, Mairaj Ahmed Zubair, Swaleha Mahmood, Anjum Gupta, Pushpa Khan, Aijaz A Gupta, Umesh D Arora, Ashish Owais, Mohammad |
| description | The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis.
The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice.
Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challenged with Mycobacterium tuberculosis infection.
The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protection against M. tuberculosis infection. |
| doi_str_mv | 10.1371/journal.pone.0022889 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1307672231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476882757</galeid><doaj_id>oai_doaj_org_article_8bf7456ea53b41b38ec7a99414e4e65c</doaj_id><sourcerecordid>A476882757</sourcerecordid><originalsourceid>FETCH-LOGICAL-c691t-cc1ecc010783c91fc84e0bdd6035207dee74ef6b1606efe97aa016f64191ab6f3</originalsourceid><addsrcrecordid>eNqNkl1r2zAYhc3YWLtu_2BsgsFgF8kkS5bsm0HpvgKFQvdxK2T5taNgS6kkl-Zmv33K4pYYNhi-kJGe9-jocLLsJcFLQgV5v3Gjt6pfbp2FJcZ5XpbVo-yUVDRf8BzTx0f_J9mzEDYYF7Tk_Gl2kpOyoLhgp9mv649I2Wg6sKhWARpklXW3SmtjAZlhq3wMqHe2QxH8gLbeRdDRuITvkLHNmMAODTA4v0MeQrITAKlOGRsigrsteDOAjapHw-j3onGsweuxd8GE59mTVvUBXkzrWfbj86fvF18Xl1dfVhfnlwvNKxIXWhPQGhMsSqor0uqSAa6bhmNa5Fg0AIJBy2vCMYcWKqEUJrzljFRE1bylZ9nrg-42XSun6IIkFAsu8pySRKwOROPURm6TaeV30ikj_2w438kUhdE9yLJuBSs4qILWjNS0BC1UVTHCgAEvdNL6MN021gM0Oj3fq34mOj-xZi07dyspKVhF9mbeTALe3YwQ4j8sT1SnkitjW5fE9GCCludM8LLMRSEStfwLlb4GBqNTeVqT9mcD72YDiYlwFzs1hiBX367_n736OWffHrFrUH1cB9eP-zKFOcgOoPYuBA_tQ3IEy33379OQ--7Lqftp7NVx6g9D92WnvwEfHwKa</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1307672231</pqid></control><display><type>article</type><title>RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Ansari, Mairaj Ahmed ; Zubair, Swaleha ; Mahmood, Anjum ; Gupta, Pushpa ; Khan, Aijaz A ; Gupta, Umesh D ; Arora, Ashish ; Owais, Mohammad</creator><contributor>Tailleux, Ludovic</contributor><creatorcontrib>Ansari, Mairaj Ahmed ; Zubair, Swaleha ; Mahmood, Anjum ; Gupta, Pushpa ; Khan, Aijaz A ; Gupta, Umesh D ; Arora, Ashish ; Owais, Mohammad ; Tailleux, Ludovic</creatorcontrib><description>The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis.
The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice.
Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challenged with Mycobacterium tuberculosis infection.
The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protection against M. tuberculosis infection.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0022889</identifier><identifier>PMID: 21853054</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Antigens ; Antigens, Bacterial - immunology ; Bacillus Calmette-Guerin vaccine ; BCG ; Biology ; Biomarkers - metabolism ; Biotechnology ; Brucellosis ; Cell Proliferation ; Cloning ; Cytokines ; Cytokines - metabolism ; Cytotoxicity ; Delivery scheduling ; ESAT-6 antigen ; Flow Cytometry ; Genomes ; Humans ; Immunization ; Immunoglobulin G - immunology ; Immunologic Memory - immunology ; Immunological memory ; Immunology ; Infections ; Interdisciplinary aspects ; Laboratories ; Leishmania major ; Leukemia ; Lipids ; Lung - immunology ; Lung - microbiology ; Lung - pathology ; Lymphocytes ; Lymphocytes T ; Medical research ; Medicine ; Mice ; Mice, Inbred BALB C ; Mortality ; Mycobacterium bovis ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - immunology ; Nanoparticles - therapeutic use ; Proteins ; Schedules ; T cells ; Th1 Cells - cytology ; Th1 Cells - immunology ; Time Factors ; Tuberculosis ; Tuberculosis - immunology ; Tuberculosis - microbiology ; Tuberculosis - prevention & control ; Tuberculosis Vaccines - immunology ; Vaccines ; Virulence (Microbiology)</subject><ispartof>PloS one, 2011-08, Vol.6 (8), p.e22889</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Ansari et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Ansari et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-cc1ecc010783c91fc84e0bdd6035207dee74ef6b1606efe97aa016f64191ab6f3</citedby><cites>FETCH-LOGICAL-c691t-cc1ecc010783c91fc84e0bdd6035207dee74ef6b1606efe97aa016f64191ab6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154911/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154911/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21853054$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Tailleux, Ludovic</contributor><creatorcontrib>Ansari, Mairaj Ahmed</creatorcontrib><creatorcontrib>Zubair, Swaleha</creatorcontrib><creatorcontrib>Mahmood, Anjum</creatorcontrib><creatorcontrib>Gupta, Pushpa</creatorcontrib><creatorcontrib>Khan, Aijaz A</creatorcontrib><creatorcontrib>Gupta, Umesh D</creatorcontrib><creatorcontrib>Arora, Ashish</creatorcontrib><creatorcontrib>Owais, Mohammad</creatorcontrib><title>RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis.
The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice.
Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challenged with Mycobacterium tuberculosis infection.
The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protection against M. tuberculosis infection.</description><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacillus Calmette-Guerin vaccine</subject><subject>BCG</subject><subject>Biology</subject><subject>Biomarkers - metabolism</subject><subject>Biotechnology</subject><subject>Brucellosis</subject><subject>Cell Proliferation</subject><subject>Cloning</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Cytotoxicity</subject><subject>Delivery scheduling</subject><subject>ESAT-6 antigen</subject><subject>Flow Cytometry</subject><subject>Genomes</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunoglobulin G - immunology</subject><subject>Immunologic Memory - immunology</subject><subject>Immunological memory</subject><subject>Immunology</subject><subject>Infections</subject><subject>Interdisciplinary aspects</subject><subject>Laboratories</subject><subject>Leishmania major</subject><subject>Leukemia</subject><subject>Lipids</subject><subject>Lung - immunology</subject><subject>Lung - microbiology</subject><subject>Lung - pathology</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mortality</subject><subject>Mycobacterium bovis</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Nanoparticles - therapeutic use</subject><subject>Proteins</subject><subject>Schedules</subject><subject>T cells</subject><subject>Th1 Cells - cytology</subject><subject>Th1 Cells - immunology</subject><subject>Time Factors</subject><subject>Tuberculosis</subject><subject>Tuberculosis - immunology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - prevention & control</subject><subject>Tuberculosis Vaccines - immunology</subject><subject>Vaccines</subject><subject>Virulence (Microbiology)</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl1r2zAYhc3YWLtu_2BsgsFgF8kkS5bsm0HpvgKFQvdxK2T5taNgS6kkl-Zmv33K4pYYNhi-kJGe9-jocLLsJcFLQgV5v3Gjt6pfbp2FJcZ5XpbVo-yUVDRf8BzTx0f_J9mzEDYYF7Tk_Gl2kpOyoLhgp9mv649I2Wg6sKhWARpklXW3SmtjAZlhq3wMqHe2QxH8gLbeRdDRuITvkLHNmMAODTA4v0MeQrITAKlOGRsigrsteDOAjapHw-j3onGsweuxd8GE59mTVvUBXkzrWfbj86fvF18Xl1dfVhfnlwvNKxIXWhPQGhMsSqor0uqSAa6bhmNa5Fg0AIJBy2vCMYcWKqEUJrzljFRE1bylZ9nrg-42XSun6IIkFAsu8pySRKwOROPURm6TaeV30ikj_2w438kUhdE9yLJuBSs4qILWjNS0BC1UVTHCgAEvdNL6MN021gM0Oj3fq34mOj-xZi07dyspKVhF9mbeTALe3YwQ4j8sT1SnkitjW5fE9GCCludM8LLMRSEStfwLlb4GBqNTeVqT9mcD72YDiYlwFzs1hiBX367_n736OWffHrFrUH1cB9eP-zKFOcgOoPYuBA_tQ3IEy33379OQ--7Lqftp7NVx6g9D92WnvwEfHwKa</recordid><startdate>20110811</startdate><enddate>20110811</enddate><creator>Ansari, Mairaj Ahmed</creator><creator>Zubair, Swaleha</creator><creator>Mahmood, Anjum</creator><creator>Gupta, Pushpa</creator><creator>Khan, Aijaz A</creator><creator>Gupta, Umesh D</creator><creator>Arora, Ashish</creator><creator>Owais, Mohammad</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110811</creationdate><title>RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis</title><author>Ansari, Mairaj Ahmed ; Zubair, Swaleha ; Mahmood, Anjum ; Gupta, Pushpa ; Khan, Aijaz A ; Gupta, Umesh D ; Arora, Ashish ; Owais, Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-cc1ecc010783c91fc84e0bdd6035207dee74ef6b1606efe97aa016f64191ab6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, Bacterial - immunology</topic><topic>Bacillus Calmette-Guerin vaccine</topic><topic>BCG</topic><topic>Biology</topic><topic>Biomarkers - metabolism</topic><topic>Biotechnology</topic><topic>Brucellosis</topic><topic>Cell Proliferation</topic><topic>Cloning</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Cytotoxicity</topic><topic>Delivery scheduling</topic><topic>ESAT-6 antigen</topic><topic>Flow Cytometry</topic><topic>Genomes</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunoglobulin G - immunology</topic><topic>Immunologic Memory - immunology</topic><topic>Immunological memory</topic><topic>Immunology</topic><topic>Infections</topic><topic>Interdisciplinary aspects</topic><topic>Laboratories</topic><topic>Leishmania major</topic><topic>Leukemia</topic><topic>Lipids</topic><topic>Lung - immunology</topic><topic>Lung - microbiology</topic><topic>Lung - pathology</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mortality</topic><topic>Mycobacterium bovis</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - immunology</topic><topic>Nanoparticles - therapeutic use</topic><topic>Proteins</topic><topic>Schedules</topic><topic>T cells</topic><topic>Th1 Cells - cytology</topic><topic>Th1 Cells - immunology</topic><topic>Time Factors</topic><topic>Tuberculosis</topic><topic>Tuberculosis - immunology</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis - prevention & control</topic><topic>Tuberculosis Vaccines - immunology</topic><topic>Vaccines</topic><topic>Virulence (Microbiology)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ansari, Mairaj Ahmed</creatorcontrib><creatorcontrib>Zubair, Swaleha</creatorcontrib><creatorcontrib>Mahmood, Anjum</creatorcontrib><creatorcontrib>Gupta, Pushpa</creatorcontrib><creatorcontrib>Khan, Aijaz A</creatorcontrib><creatorcontrib>Gupta, Umesh D</creatorcontrib><creatorcontrib>Arora, Ashish</creatorcontrib><creatorcontrib>Owais, Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ansari, Mairaj Ahmed</au><au>Zubair, Swaleha</au><au>Mahmood, Anjum</au><au>Gupta, Pushpa</au><au>Khan, Aijaz A</au><au>Gupta, Umesh D</au><au>Arora, Ashish</au><au>Owais, Mohammad</au><au>Tailleux, Ludovic</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-08-11</date><risdate>2011</risdate><volume>6</volume><issue>8</issue><spage>e22889</spage><pages>e22889-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The absence of certain genomic loci that are present in most of the virulent strains of Mycobacterium tuberculosis as well as lack of lasting memory responses are some of the major causes attributed to the non effectiveness of Bacille Calmette-Gue'rin (BCG) vaccine. Immunization schedules addressing these issues can offer better strategy for protection against tuberculosis.
The immunological responses evoked upon administration of archaeosome based antigen delivery system comprising T cell antigen, Rv3619c (an ESAT-6 family protein), has been assessed against experimental murine tuberculosis in BALB/c mice.
Archaeosome based subunit vaccine has been found to elicit type-1 cytokines in the immunized mice. Besides effective T cell memory response, the Rv3619c based vaccine was able to reduce mycobacterial burden in the animals challenged with Mycobacterium tuberculosis infection.
The data of the present study suggest that archaeosome encapsulated RD gene products offer substantial protection against M. tuberculosis infection.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21853054</pmid><doi>10.1371/journal.pone.0022889</doi><tpages>e22889</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-08, Vol.6 (8), p.e22889 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1307672231 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Antigens Antigens, Bacterial - immunology Bacillus Calmette-Guerin vaccine BCG Biology Biomarkers - metabolism Biotechnology Brucellosis Cell Proliferation Cloning Cytokines Cytokines - metabolism Cytotoxicity Delivery scheduling ESAT-6 antigen Flow Cytometry Genomes Humans Immunization Immunoglobulin G - immunology Immunologic Memory - immunology Immunological memory Immunology Infections Interdisciplinary aspects Laboratories Leishmania major Leukemia Lipids Lung - immunology Lung - microbiology Lung - pathology Lymphocytes Lymphocytes T Medical research Medicine Mice Mice, Inbred BALB C Mortality Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Nanoparticles - therapeutic use Proteins Schedules T cells Th1 Cells - cytology Th1 Cells - immunology Time Factors Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis - prevention & control Tuberculosis Vaccines - immunology Vaccines Virulence (Microbiology) |
| title | RD antigen based nanovaccine imparts long term protection by inducing memory response against experimental murine tuberculosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-03T11%3A31%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=RD%20antigen%20based%20nanovaccine%20imparts%20long%20term%20protection%20by%20inducing%20memory%20response%20against%20experimental%20murine%20tuberculosis&rft.jtitle=PloS%20one&rft.au=Ansari,%20Mairaj%20Ahmed&rft.date=2011-08-11&rft.volume=6&rft.issue=8&rft.spage=e22889&rft.pages=e22889-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0022889&rft_dat=%3Cgale_plos_%3EA476882757%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1307672231&rft_id=info:pmid/21853054&rft_galeid=A476882757&rft_doaj_id=oai_doaj_org_article_8bf7456ea53b41b38ec7a99414e4e65c&rfr_iscdi=true |