Targeted over-expression of glutamate transporter 1 (GLT-1) reduces ischemic brain injury in a rat model of stroke

Following the onset of an ischemic brain injury, the excitatory neurotransmitter glutamate is released. The excitotoxic effects of glutamate are a major contributor to the pathogenesis of a stroke. The aim of this study was to examine if overexpression of a glutamate transporter (GLT-1) reduces isch...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e22135-e22135
Hauptverfasser:	Harvey, Brandon K, Airavaara, Mikko, Hinzman, Jason, Wires, Emily M, Chiocco, Matthew J, Howard, Douglas B, Shen, Hui, Gerhardt, Greg, Hoffer, Barry J, Wang, Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport System X-AG - metabolism Amino acids Amperometry Animal behavior Animals Behavior, Animal - physiology Biology Brain Brain damage Brain Infarction - complications Brain Infarction - pathology Brain Infarction - physiopathology Brain injuries Brain Injuries - complications Brain Injuries - pathology Brain Injuries - physiopathology Brain Injuries - prevention & control Brain injury Brain Ischemia - complications Brain Ischemia - pathology Brain Ischemia - physiopathology Brain Ischemia - prevention & control Cell death Cerebral blood flow Cerebral Cortex - metabolism Cerebral Cortex - pathology Cerebral Cortex - physiopathology Cerebral infarction Cortex Damage assessment Data recovery Deoxyribonucleic acid Dependovirus Disease Models, Animal DNA DNA fragmentation Electrical measurement Excitotoxicity Gene Expression Regulation Gene therapy Gene transfer Glutamate Glutamates - metabolism Glutamic acid transporter Head injuries HEK293 Cells Hostages Humans In Situ Nick-End Labeling In vivo methods and tests Infarction Infarction, Middle Cerebral Artery - complications Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - physiopathology Injuries Injury prevention Ischemia Male Microdialysis Neurophysiology Occlusion Overexpression Overflow Pathogenesis Rats Rats, Inbred F344 Recovery of Function - physiology Stroke Stroke - complications Stroke - pathology Stroke - physiopathology
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