Plasmodium falciparum: differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo

The African continent is currently experiencing rapid population growth, with rising urbanization increasing the percentage of the population living in large towns and cities. We studied the impact of the degree of urbanization on the population genetics of Plasmodium falciparum in urban and peri-ur...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e23430
Hauptverfasser:	Tsumori, Yoko, Ndounga, Mathieu, Sunahara, Toshihiko, Hayashida, Nozomi, Inoue, Megumi, Nakazawa, Shusuke, Casimiro, Prisca, Isozumi, Rie, Uemura, Haruki, Tanabe, Kazuyuki, Kaneko, Osamu, Culleton, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Alleles Analysis Animals Anopheles - growth & development Anopheles - parasitology Antimalarials - pharmacology Aquatic insects Biodiversity Biology Chloroquine Chloroquine - pharmacology Clinical trials Computers Congo Dihydrofolate reductase Disease transmission Drug resistance Drug Resistance - genetics Epidemiology Erythrocytes Female Gene Frequency Gene polymorphism Gene sequencing Genetic diversity Genetic markers Genetic polymorphisms Genetic Variation Genetics Genomics Haplotypes Haplotypes - genetics Heterozygosity Humans Infections Infectious diseases Insect Vectors - growth & development Insect Vectors - parasitology Laboratories Linkage disequilibrium Malaria Malaria, Falciparum - parasitology Malaria, Falciparum - prevention & control Malaria, Falciparum - transmission Male Markers Medicine Membrane Transport Proteins - genetics Merozoite Surface Protein 1 - genetics Metropolitan areas Microsatellites MSP-1 gene Mutation Parasites Plasmodium falciparum Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - growth & development Polymorphism Population Population genetics Population growth Population structure Protozoan Proteins - genetics Pyrimethamine Pyrimethamine - pharmacology Rural urban migration Selection, Genetic Studies Tetrahydrofolate dehydrogenase Tetrahydrofolate Dehydrogenase - genetics Urban areas Urbanization Vector-borne diseases Young Adult
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