Drosophila Ten-m and filamin affect motor neuron growth cone guidance

The Drosophila Ten-m (also called Tenascin-major, or odd Oz (odz)) gene has been associated with a pair-rule phenotype. We identified and characterized new alleles of Drosophila Ten-m to establish that this gene is not responsible for segmentation defects but rather causes defects in motor neuron ax...

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Veröffentlicht in:	PloS one 2011-08, Vol.6 (8), p.e22956-e22956
Hauptverfasser:	Zheng, Lihua, Michelson, Yehudit, Freger, Vita, Avraham, Ziva, Venken, Koen J T, Bellen, Hugo J, Justice, Monica J, Wides, Ron
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Animals, Genetically Modified Axon guidance Biology Body Patterning - genetics Central nervous system Cones Contractile Proteins - genetics Contractile Proteins - metabolism Defects Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Ectoderm - cytology Ectoderm - embryology Ectoderm - metabolism Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Embryogenesis Embryonic development Embryonic growth stage Female Filamins Fluorescent Antibody Technique Genes Genetic aspects Genetics Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Growth Growth cones Growth Cones - metabolism Immunohistochemistry Insects Life sciences M protein Male Medicine Microfilament Proteins - genetics Microfilament Proteins - metabolism Motor Neurons - metabolism Mutants Mutation Neurons Overexpression Phenotype Phenotypes Protein Binding Proteins Rodents Routing Segmentation Tenascin Tenascin - genetics Tenascin - metabolism Transcription factors Trends Two-Hybrid System Techniques Vertebrates
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