LGR5 is a negative regulator of tumourigenicity, antagonizes Wnt signalling and regulates cell adhesion in colorectal cancer cell lines

LGR5 (Leucine-rich repeat-containing G-protein coupled receptor 5) is the most established marker for intestinal stem cells. Mouse models show that LGR5+ cells are the cells of origin of intestinal cancer, and LGR5 expression is elevated in human colorectal cancers, however very little is known abou...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22733-e22733
Hauptverfasser:	Walker, Francesca, Zhang, Hui-Hua, Odorizzi, Annalisa, Burgess, Antony W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion Analysis Animal models Animals Biology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biotechnology Blotting, Western Cancer Cell adhesion Cell adhesion & migration Cell Adhesion - physiology Cell Movement Cell Proliferation Colony-Forming Units Assay Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Development and progression Fluorescent Antibody Technique G protein-coupled receptors Gene expression Gene Expression Profiling Genes Humans Intestine Invasiveness Kinases Leucine Mice Mice, Nude Mutation Oligonucleotide Array Sequence Analysis Receptors, G-Protein-Coupled - antagonists & inhibitors Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics RNA-mediated interference Rodents Signaling Stem cell transplantation Stem cells Tumor cell lines Tumor Cells, Cultured Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism Wound Healing Xenograft Model Antitumor Assays Xenografts
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