L-Ilf3 and L-NF90 traffic to the nucleolus granular component: alternatively-spliced exon 3 encodes a nucleolar localization motif

Ilf3 and NF90, two proteins containing double-stranded RNA-binding domains, are generated by alternative splicing and involved in several functions. Their heterogeneity results from posttranscriptional and posttranslational modifications. Alternative splicing of exon 3, coding for a 13 aa N-terminal...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22296
Hauptverfasser:	Viranaicken, Wildriss, Gasmi, Laila, Chaumet, Alexandre, Durieux, Christiane, Georget, Virginie, Denoulet, Philippe, Larcher, Jean-Christophe
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Alternative Splicing - drug effects Alternative Splicing - genetics Amino Acid Motifs Amino Acid Sequence Amino Acid Substitution - genetics Biochemistry, Molecular Biology Biology Cell Nucleolus - drug effects Cell Nucleolus - metabolism Confocal microscopy Dichlororibofuranosylbenzimidazole - pharmacology Double-stranded RNA Exons - genetics Fluorescence Recovery After Photobleaching Fractionation Gene expression Gene polymorphism Green Fluorescent Proteins - metabolism HeLa Cells Humans Isoforms Kinases Laboratories Life Sciences Localization Microscopy Molecular Sequence Data Mutants Nuclear Factor 90 Proteins - chemistry Nuclear Factor 90 Proteins - genetics Nuclear Factor 90 Proteins - metabolism Nucleoli Plasmids Polymorphism Post-transcription Protein A Protein Isoforms - genetics Protein Isoforms - metabolism Protein Sorting Signals - drug effects Protein Transport - drug effects Proteins Recombinant Fusion Proteins - metabolism Recombinant proteins Recovery (Medical) Ribonucleic acid RNA RNA Isoforms - genetics Sequence Deletion - genetics Subcellular Fractions - drug effects Subcellular Fractions - metabolism Trends
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