Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells

The Wnt/β-catenin signaling pathway is involved in the normal development of thyroid gland, but its disregulation provokes the appearance of several types of cancers, including papillary thyroid carcinomas (PTC) which are the most common thyroid tumours. The follow-up of PTC patients is based on the...

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Veröffentlicht in:	PloS one 2011, Vol.6 (7), p.e22280-e22280
Hauptverfasser:	Gilbert-Sirieix, Marie, Makoukji, Joelle, Kimura, Shioko, Talbot, Monique, Caillou, Bernard, Massaad, Charbel, Massaad-Massade, Liliane
Format:	Artikel
Sprache:	eng
Schlagworte:	beta Catenin - genetics beta Catenin - metabolism Biology Blotting, Western Breast cancer Carcinoma, Papillary - genetics Carcinoma, Papillary - metabolism Cell Differentiation Cell growth Chromatin Immunoprecipitation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Enhancer Elements, Genetic - genetics Experiments Gene expression Humans Immunoenzyme Techniques Immunofluorescence Immunoglobulins Kinases LEF protein Ligands Lithium Lithium chloride Lithium Chloride - pharmacology Localization Luciferases - metabolism Medicine MicroRNAs Microscopy Mimicry Molecular modelling Papillary thyroid carcinoma Polymerase chain reaction Promoter Regions, Genetic - genetics Proteins Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Signal transduction Signaling siRNA Studies TCF Transcription Factors - genetics TCF Transcription Factors - metabolism Thyroglobulin Thyroid Thyroid cancer Thyroid gland Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid transcription factor 1 Tissues Transcription Factors Tumor Cells, Cultured Tumors Wnt protein Wnt Proteins - genetics Wnt Proteins - metabolism Wnt Signaling Pathway Xenopus β-Catenin
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