Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection

A safe, efficacious vaccine is required to stop the AIDS pandemic. Disappointing results from the STEP trial implied a need to include humoral anti-HIV-1 responses, a notion supported by RV144 trial data even though correlates of protection are unknown. We vaccinated rhesus macaques with recombinant...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22010-e22010
Hauptverfasser:	Lakhashe, Samir K, Wang, Wendy, Siddappa, Nagadenahalli B, Hemashettar, Girish, Polacino, Patricia, Hu, Shiu-Lok, Villinger, François, Else, James G, Novembre, Francis J, Yoon, John K, Lee, Sandra J, Montefiori, David C, Ruprecht, Ruth M, Rasmussen, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS AIDS vaccines Animals Antibodies Antigens Antiviral agents Biology Cell-mediated immunity Coding Correlation Divergence Epidemics Fusion Proteins, gag-pol - immunology Gag protein Glycoprotein gp160 Health aspects HIV HIV Envelope Protein gp160 - immunology HIV Infections - immunology HIV Infections - prevention & control HIV-1 - immunology Human immunodeficiency virus Humans Immune response (humoral) Immunity Infant Macaca mulatta Medicine Mucosa Pandemics Simian Immunodeficiency Virus - immunology tat Gene Products, Human Immunodeficiency Virus - immunology Tat protein Vaccination Vaccination - methods Vaccines Vaccines, Synthetic - immunology Viral Vaccines - immunology Viremia Viremia - prevention & control Viruses
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