Amelioration of lupus nephritis by serum amyloid P component gene therapy with distinct mechanisms varied from different stage of the disease

Our previous study revealed that administration of syngeneic female BALB/c mice with excessive self activated lymphocyte-derived DNA (ALD-DNA) could induce systemic lupus erythematosus (SLE) disease, indicating that overload of self-DNA might exceed normal clearance ability and comprise the major so...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22659-e22659
Hauptverfasser:	Zhang, Weijuan, Wu, Jin, Qiao, Bin, Xu, Wei, Xiong, Sidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid P component Animals Anti-DNA antibodies Antibodies Antibodies, Antinuclear - biosynthesis Antibodies, Antinuclear - immunology Antigen-Antibody Complex - immunology Antigens Arthritis Autoantibodies Autoantigens Autoimmune diseases Autoimmunity B cells Biology Biomarkers - metabolism Blood proteins Chronic conditions Deoxyribonucleic acid Deposition DNA DNA - immunology DNA - metabolism Female Gene therapy Genetic Therapy - methods Hepatitis Hepatology Immune clearance Immune response Immune system Immunity, Innate - genetics Immunoglobulins Immunology Infiltration Inflammation Inflammation - genetics Inflammation - immunology Inflammation - therapy Innate immunity Leukocytes - immunology Leukocytes - metabolism Ligands Liver cancer Lupus Lupus nephritis Lupus Nephritis - genetics Lupus Nephritis - immunology Lupus Nephritis - therapy Lymphocyte Activation - genetics Lymphocytes Medical treatment Medicine Mice Mice, Inbred BALB C Neisseria meningitidis Nephritis Pathogenesis Plasmids - genetics Protein binding Proteins Proteinuria SAP protein Senescence Serum Amyloid P-Component - administration & dosage Serum Amyloid P-Component - genetics Serum Amyloid P-Component - metabolism Serum Amyloid P-Component - therapeutic use Stem cells Systemic lupus erythematosus Tumor necrosis factor-TNF Urine
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