Proteomic biomarkers for acute interstitial lung disease in gefitinib-treated Japanese lung cancer patients

Interstitial lung disease (ILD) events have been reported in Japanese non-small-cell lung cancer (NSCLC) patients receiving EGFR tyrosine kinase inhibitors. We investigated proteomic biomarkers for mechanistic insights and improved prediction of ILD. Blood plasma was collected from 43 gefitinib-trea...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22062-e22062
Hauptverfasser:	Nyberg, Fredrik, Ogiwara, Atsushi, Harbron, Chris G, Kawakami, Takao, Nagasaka, Keiko, Takami, Sachiko, Wada, Kazuya, Tu, Hsiao-Kun, Otsuji, Makiko, Kyono, Yutaka, Dobashi, Tae, Komatsu, Yasuhiko, Kihara, Makoto, Akimoto, Shingo, Peers, Ian S, South, Marie C, Higenbottam, Tim, Fukuoka, Masahiro, Nakata, Koichiro, Ohe, Yuichiro, Kudoh, Shoji, Clausen, Ib Groth, Nishimura, Toshihide, Marko-Varga, György, Kato, Harubumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Asian Continental Ancestry Group Biological markers Biology Biomarkers Biomarkers - blood Blood plasma Cancer Cancer patients Cancer research Cancer therapies Carcinoma, Non-Small-Cell Lung - complications Carcinoma, Non-Small-Cell Lung - drug therapy Care and treatment Chemotherapy Chromatography Chromatography, Liquid Cytokines Databases, Protein Diagnosis Diagnostic systems Discriminant Analysis Epidermal growth factor receptors Gefitinib Gene expression Hospitals Humans Lung cancer Lung diseases Lung Diseases, Interstitial - blood Lung Diseases, Interstitial - complications Lung Diseases, Interstitial - diagnosis Lung Neoplasms - complications Lung Neoplasms - drug therapy Mass spectrometry Mass spectroscopy Medicin och hälsovetenskap Medicine Non-small cell lung cancer Non-small cell lung carcinoma Oncology Patients Peptides - blood Peptides - isolation & purification Pharmacology Phenols Phenotype Predictions Principal components analysis Protein-tyrosine kinase Proteins Proteomics Proteomics - methods Quality Control Quality management Quinazolines - therapeutic use R&D Reproducibility of Results Research & development Scaling Scientific imaging Statistical analysis Studies Surgery Tandem Mass Spectrometry Tyrosine Western blotting
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