Genome-wide association scan in HIV-1-infected individuals identifying variants influencing disease course

AIDS develops typically after 7-11 years of untreated HIV-1 infection, with extremes of very rapid disease progression (15 years). To reveal additional host genetic factors that may impact on the clinical course of HIV-1 infection, we designed a genome-wide association study (GWAS) in 404 participan...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22208-e22208
Hauptverfasser:	van Manen, Daniëlle, Delaneau, Olivier, Kootstra, Neeltje A, Boeser-Nunnink, Brigitte D, Limou, Sophie, Bol, Sebastiaan M, Burger, Judith A, Zwinderman, Aeilko H, Moerland, Perry D, van 't Slot, Ruben, Zagury, Jean-François, van 't Wout, Angélique B, Schuitemaker, Hanneke
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Analysis Bioinformatics Biology Chemokines Cohort analysis Cohort Studies Cytokines Development and progression Diagnosis Disease Progression Disease resistance Epidemiology Female Genetic aspects Genetic factors Genetic research Genome, Human - genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotypes Health aspects HIV HIV Infections - genetics HIV Infections - virology HIV-1 - physiology Human immunodeficiency virus Humans Immunology Infection Infections Infectious diseases Laboratories Male Medical research Medicine Middle Aged Mortality Netherlands Polymorphism, Single Nucleotide - genetics Regression analysis Seroconversion Sexual behavior Single-nucleotide polymorphism Survival Analysis Viral Load - genetics Viruses Young Adult
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