Energy metabolism in H460 lung cancer cells: effects of histone deacetylase inhibitors

Tumor cells are characterized by accelerated growth usually accompanied by up-regulated pathways that ultimately increase the rate of ATP production. These cells can suffer metabolic reprogramming, resulting in distinct bioenergetic phenotypes, generally enhancing glycolysis channeled to lactate pro...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22264-e22264
Hauptverfasser:	Amoêdo, Nívea Dias, Rodrigues, Mariana Figueiredo, Pezzuto, Paula, Galina, Antonio, da Costa, Rodrigo Madeiro, de Almeida, Fábio Ceneviva Lacerda, El-Bacha, Tatiana, Rumjanek, Franklin David
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis ATP Bioenergetics Biology Biosynthesis Butyrates - pharmacology Cancer Cell cycle Cell Cycle - drug effects Cell Differentiation - drug effects Cell Line, Tumor Cell Membrane Permeability - drug effects Cell Proliferation - drug effects Cell Respiration - drug effects Cell Shape - drug effects Chromatin Cytochrome Dehydrogenases Deoxyribonucleic acid DNA Electron transport Energy metabolism Energy Metabolism - drug effects Enzymes Esters Fatty acids Gene expression Glucose 1-Dehydrogenase - metabolism Glucose metabolism Glucose transporter Glucose Transporter Type 1 - metabolism Glucose Transporter Type 3 - metabolism Glycolysis Glycolysis - drug effects Hexokinase Hexokinase - metabolism Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Humans Hydroxamic Acids - pharmacology Hypotheses Inhibitors Kinases L-Lactate dehydrogenase L-Lactate Dehydrogenase - metabolism Lactate dehydrogenase Lactates - metabolism Lactic acid Lung cancer Lung diseases Lung Neoplasms - enzymology Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine Metabolism Metabolites Metabolomics Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Oxidation Oxidative metabolism Oxidative phosphorylation Oxygen Oxygen consumption Pentose Pentose phosphate pathway Phosphates Phosphorylation Physiological aspects Protein Binding - drug effects Protein biosynthesis Protein folding Protein synthesis Proteins Pyruvate kinase Pyruvate Kinase - metabolism Pyruvic acid Respirometry RNA Rodents Sodium Sodium butyrate Succinate Dehydrogenase - metabolism Trends Trichostatin A Tumor cells
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