Liver-derived IGF-I regulates mean life span in mice

Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span. Serum I...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22640-e22640
Hauptverfasser:	Svensson, Johan, Sjögren, Klara, Fäldt, Jenny, Andersson, Niklas, Isaksson, Olle, Jansson, John-Olov, Ohlsson, Claes
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Analysis Animals Approximation Biology Body Composition - genetics Body fat Body weight Body Weight - genetics Cardiomyocytes Collagen Connective tissue growth factor Connective tissues Cytokines Deactivation Drosophila melanogaster Drug dosages Eating - genetics Endocrinology and Diabetes Endokrinologi och diabetes Energy expenditure Energy measurement Experiments Female Fertility Fertility - genetics Food Gene expression Gene Expression Regulation Gene regulation Genes Genetic engineering Growth hormones Heat shock Heat shock proteins House mouse Inactivation Insects Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - deficiency Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Insulin-like growth factors Internal medicine Life expectancy Life span Liver Liver - metabolism Longevity Longevity - genetics Longevity - physiology Male MEDICAL AND HEALTH SCIENCES MEDICIN OCH HÄLSOVETENSKAP Medicine Mice Mutation Neurophysiology Neurosciences Oligonucleotide Array Sequence Analysis Organ Specificity Organs Oxidative stress Oxygen Oxygen consumption Oxygen Consumption - genetics Physiology Polymerase chain reaction Reverse Transcriptase Polymerase Chain Reaction Rodents Transgenic animals Transgenic mice Trends Weight reduction
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Zusammenfassung:	Transgenic mice with low levels of global insulin-like growth factor-I (IGF-I) throughout their life span, including pre- and postnatal development, have increased longevity. This study investigated whether specific deficiency of liver-derived, endocrine IGF-I is of importance for life span. Serum IGF-I was reduced by approximately 80% in mice with adult, liver-specific IGF-I inactivation (LI-IGF-I(-/-) mice), and body weight decreased due to reduced body fat. The mean life span of LI-IGF-I(-/-) mice (n = 84) increased 10% vs. control mice (n = 137) (Cox's test, p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0022640