Adenovirus-vectored drug-vaccine duo as a rapid-response tool for conferring seamless protection against influenza
Few other diseases exert such a huge toll of suffering as influenza. We report here that intranasal (i.n.) administration of E1/E3-defective (ΔE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in m...
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| Veröffentlicht in: | PloS one 2011-07, Vol.6 (7), p.e22605-e22605 |
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| creator | Zhang, Jianfeng Tarbet, E Bart Feng, Tsungwei Shi, Zhongkai Van Kampen, Kent R Tang, De-chu C |
| description | Few other diseases exert such a huge toll of suffering as influenza. We report here that intranasal (i.n.) administration of E1/E3-defective (ΔE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in mice. By encoding an influenza virus (IFV) hemagglutinin (HA) HA1 domain, an Ad5-HA1 vector conferred rapid protection as a prophylactic drug followed by elicitation of sustained protective immunity as a vaccine for inducing seamless protection against influenza as a drug-vaccine duo (DVD) in a single package. Since Ad5 particles induce a complex web of host responses, which could arrest influenza by activating a specific arm of innate immunity to impede IFV growth in the airway, it is conceivable that this multi-pronged influenza DVD may escape the fate of drug resistance that impairs the current influenza drugs. |
| doi_str_mv | 10.1371/journal.pone.0022605 |
| format | Article |
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We report here that intranasal (i.n.) administration of E1/E3-defective (ΔE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in mice. By encoding an influenza virus (IFV) hemagglutinin (HA) HA1 domain, an Ad5-HA1 vector conferred rapid protection as a prophylactic drug followed by elicitation of sustained protective immunity as a vaccine for inducing seamless protection against influenza as a drug-vaccine duo (DVD) in a single package. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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We report here that intranasal (i.n.) administration of E1/E3-defective (ΔE1E3) adenovirus serotype 5 (Ad5) particles rapidly induced an anti-influenza state as a means of prophylactic therapy which persisted for several weeks in mice. By encoding an influenza virus (IFV) hemagglutinin (HA) HA1 domain, an Ad5-HA1 vector conferred rapid protection as a prophylactic drug followed by elicitation of sustained protective immunity as a vaccine for inducing seamless protection against influenza as a drug-vaccine duo (DVD) in a single package. Since Ad5 particles induce a complex web of host responses, which could arrest influenza by activating a specific arm of innate immunity to impede IFV growth in the airway, it is conceivable that this multi-pronged influenza DVD may escape the fate of drug resistance that impairs the current influenza drugs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21818346</pmid><doi>10.1371/journal.pone.0022605</doi><tpages>e22605</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenoviridae - genetics Adenoviruses Animals Antibodies, Viral - blood Antiviral Agents - therapeutic use Biology Drug resistance Drug therapy Drugs Genetic Vectors - genetics Health Status Hemagglutinins Humans Immunity Immunoglobulins Influenza Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - immunology Influenza viruses Influenza, Human - drug therapy Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Innate immunity Lung - immunology Lung - pathology Lung - virology Medicine Mice Optical disks Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Preventive medicine Respiratory tract Vaccination Vaccines Viruses Weight Loss |
| title | Adenovirus-vectored drug-vaccine duo as a rapid-response tool for conferring seamless protection against influenza |
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