The X-linked tumor suppressor TSPX interacts and promotes degradation of the hepatitis B viral protein HBx via the proteasome pathway

Hepatitis B virus (HBV) infection is a major risk for hepatocellular carcinoma (HCC), and it is a serious global health problem with two billion people exposed to it worldwide. HBx, an essential factor for viral replication and a putative oncoprotein encoded by the HBV genome, has been shown to prom...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22979-e22979
Hauptverfasser:	Kido, Tatsuo, Ou, Jing-Hsiung James, Lau, Yun-Fai Chris
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Blotting, Western Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cell cycle Cell division Cell growth Cells, Cultured Degradation Development and progression DNA-Binding Proteins Gene expression Genomes Global health Health aspects Health risks Hepatitis Hepatitis B Hepatitis B virus Hepatocellular carcinoma Hepatocytes Humans Infection Infections Kidney - cytology Kidney - metabolism Kinases Liver Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Males Medicine Mutation Nuclear Proteins - antagonists & inhibitors Nuclear Proteins - genetics Nuclear Proteins - metabolism Overexpression Proteasome Endopeptidase Complex - metabolism Proteasomes Protein Processing, Post-Translational Proteins Public health Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Small Interfering - genetics Signal transduction Stability Trans-Activators - genetics Trans-Activators - metabolism Trends Tumor suppressor genes Tumorigenesis Tumors Ubiquitin Ubiquitin - metabolism Viral proteins Viral Regulatory and Accessory Proteins Viruses
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