Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs)

Metformin, an oral insulin-sensitizing drug, is actively transported into cells by organic cation transporters (OCT) 1, 2, and 3 (encoded by SLC22A1, SLC22A2, or SLC22A3), which are tissue specifically expressed at significant levels in various organs such as liver, muscle, and kidney. Because metfo...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22163
Hauptverfasser:	Nies, Anne T, Hofmann, Ute, Resch, Claudia, Schaeffeler, Elke, Rius, Maria, Schwab, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Pyridinylmethylsulfinylbenzimidazoles - pharmacology Annual reports Antidiabetics Biological Transport - drug effects Biology Cations Cell Line Cell lines Coding Computer applications Diabetes Diabetes therapy Drug dosages Drug interaction Drug interactions Drug metabolism Fasting Gastroesophageal reflux Humans Imidazoles - pharmacology Immunoblotting Inhibitors Inhibitory Concentration 50 Insulin Kidneys Lansoprazole Ligands Liver Medicine Metabolism Metformin Metformin - metabolism Oct-2 protein Oct-4 protein Omeprazole Omeprazole - analogs & derivatives Omeprazole - pharmacology Organic Cation Transport Proteins - genetics Organic Cation Transport Proteins - metabolism Organic Cation Transporter 1 - genetics Organic Cation Transporter 1 - metabolism Organic Cation Transporter 2 Organs Pharmacology Physiological aspects Protein Binding - drug effects Proton pump inhibitors Proton Pump Inhibitors - pharmacology Rabeprazole Rabeprazole sodium Rodents Sensitizing Substrates Type 2 diabetes
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