Subdominant/cryptic CD8 T cell epitopes contribute to resistance against experimental infection with a human protozoan parasite

During adaptive immune response, pathogen-specific CD8(+) T cells recognize preferentially a small number of epitopes, a phenomenon known as immunodominance. Its biological implications during natural or vaccine-induced immune responses are still unclear. Earlier, we have shown that during experimen...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22011-e22011
Hauptverfasser:	Dominguez, Mariana R, Silveira, Eduardo L V, de Vasconcelos, José Ronnie C, de Alencar, Bruna C G, Machado, Alexandre V, Bruna-Romero, Oscar, Gazzinelli, Ricardo T, Rodrigues, Mauricio M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Adenoviruses Animals Antigenic determinants Antigens Biology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Deoxyribonucleic acid DNA DNA vaccines Endoplasmic reticulum Epitopes Epitopes, T-Lymphocyte - chemistry Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Experimental infection Female Gene mutation Health aspects Histocompatibility antigen H-2 House mouse Humans Hypotheses Immune response Immune system Immunity Immunization Immunodominance Immunodominant Epitopes - chemistry Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Infection Infections Interferon-gamma - metabolism Interleukin-10 - metabolism Interleukin-2 - metabolism Lymphocytes Lymphocytes T Malaria Mice Parasites Parasitism Pathogens Peptides Peptides - chemistry Peptides - immunology Plasmids Proteins Protozoa T cell receptors T cells Theileria Toxoplasma gondii trans-Sialidase Tropical diseases Trypanosoma cruzi Trypanosoma cruzi - microbiology Tumor Necrosis Factor-alpha - metabolism Vaccination Vaccine development Vaccines
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