Production of recombinant human DNA polymerase delta in a Bombyx mori bioreactor

Eukaryotic DNA polymerase δ (pol δ) plays a crucial role in chromosomal DNA replication and various DNA repair processes. It is thought to consist of p125, p66 (p68), p50 and p12 subunits. However, rigorous isolation of mammalian pol δ from natural sources has usually yielded two-subunit preparation...

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Veröffentlicht in:	PloS one 2011-07, Vol.6 (7), p.e22224-e22224
Hauptverfasser:	Zhou, Yajing, Chen, Huiqing, Li, Xiao, Wang, Yujue, Chen, Keping, Zhang, Sufang, Meng, Xiao, Lee, Ernest Y C, Lee, Marietta Y W T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Antigens Baculoviridae - genetics Base excision repair Biochemistry Biology Bioreactors Biotechnology - methods Blotting, Western Bombyx - metabolism Bombyx - virology Bombyx mori Cancer Cell cycle Chemistry Chromatography Chromatography, Affinity Chromosomes Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA polymerase DNA Polymerase III - biosynthesis DNA Polymerase III - isolation & purification DNA polymerases DNA repair DNA Repair - genetics DNA replication DNA-directed DNA polymerase Enzymes Etiology Fibroblasts Gel filtration Gene Expression Genetic Vectors - genetics Growth hormones HeLa Cells Hemolymph - metabolism Homogeneity Humans Insect cells Insects Larva - virology Larvae Life sciences Molecular biology Molecular Weight Mutation Polypeptides Protein Subunits - metabolism Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification Recombination, Genetic - genetics Repair Rodents Saccharomyces cerevisiae Subcellular Fractions - metabolism Uracil Yeast
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