Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos
In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Mult...
Gespeichert in:
| Veröffentlicht in: | PloS one 2011-07, Vol.6 (7), p.e21741-e21741 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e21741 |
|---|---|
| container_issue | 7 |
| container_start_page | e21741 |
| container_title | PloS one |
| container_volume | 6 |
| creator | Kraeussling, Michael Wagner, Toni Ulrich Schartl, Manfred |
| description | In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio. |
| doi_str_mv | 10.1371/journal.pone.0021741 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1305271713</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A476886293</galeid><doaj_id>oai_doaj_org_article_4d9eac0c8ccf4afe9140262af4369f85</doaj_id><sourcerecordid>A476886293</sourcerecordid><originalsourceid>FETCH-LOGICAL-c757t-3445f62b87b230bcb2335c7a923329f79b40ed71f21cf9bf6cb147b9b446cf4c3</originalsourceid><addsrcrecordid>eNqNk11rFDEUhgdRbK3-A9EBQfFi13zNZOZGKEXtQqHg1204k0l2UzPJmsws7oX_3bN2W7rSCwkkwznP-2ZyklMUzymZUy7pu6s4pQB-vo7BzAlhVAr6oDimLWezmhH-8M73UfEk5ytCKt7U9ePiCOGKSNYcF7_P3XLltyXkbdCrFEOccgmh3wWGwYzJ6VJ7AxtYmrJ3G5ddDEhoHYc1hG1pIKF8TBCyTm49Yho85kdkx23pQrlOZtZ5yOPkoRxMDz-gNEOXtjE_LR5Z8Nk8268nxbePH76enc8uLj8tzk4vZlpWcpxxISpbs66RHeOk0zjzSktocWWtlW0niOkltYxq23a21h0VssOwqLUVmp8UL6991z5mta9cVpSTikkqKUdicU30Ea7UOrkB0lZFcOpvIKalgjQ6LIUSfWtAE91o9AZrWioIqxlYwevWNhV6vd_vNnV4Xm0ClscfmB5mglupZdwoTjllTYsGb_YGKf6cTB7V4LI23kMweD-qkbVsBG1qJF_9Q95_uD21BPx_F2zEbfXOU50KWTdNzdodNb-HwtGbwWl8ZdZh_EDw9kCAzGh-jUuYclaLL5__n738fsi-vsOuDPhxlaOfdm8rH4LiGtQp5pyMva0xJWrXJDfVULsmUfsmQdmLu_dzK7rpCv4HZyEP3Q</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1305271713</pqid></control><display><type>article</type><title>Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Kraeussling, Michael ; Wagner, Toni Ulrich ; Schartl, Manfred</creator><contributor>Heisenberg, Carl-Philipp</contributor><creatorcontrib>Kraeussling, Michael ; Wagner, Toni Ulrich ; Schartl, Manfred ; Heisenberg, Carl-Philipp</creatorcontrib><description>In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0021741</identifier><identifier>PMID: 21750728</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Biochemistry ; Biology ; Blastula ; Blastula - cytology ; Blastula - embryology ; Blastula - metabolism ; Caenorhabditis elegans ; Cell cycle ; Cell Cycle - genetics ; Cell division ; Cell Division - genetics ; Cyclin B1 - genetics ; Embryo, Nonmammalian - cytology ; Embryo, Nonmammalian - embryology ; Embryo, Nonmammalian - metabolism ; Embryonic development ; Embryos ; Fish ; Fish Proteins - genetics ; Gene expression ; Gene Expression Regulation, Developmental ; Genetic aspects ; Helobdella triserialis ; Histology ; Laboratories ; Localization ; Microscopy, Confocal ; Mitochondrial Proteins - genetics ; Oryzias - embryology ; Oryzias - genetics ; Oryzias - metabolism ; Oryzias latipes ; Phosphorylation ; Reverse Transcriptase Polymerase Chain Reaction ; Ribosomal Proteins - genetics ; RNA polymerase ; RNA Polymerase II - metabolism ; Synchronization ; Time Factors ; Transcription ; Transcription (Genetics) ; Transcription, Genetic ; Zebrafish</subject><ispartof>PloS one, 2011-07, Vol.6 (7), p.e21741-e21741</ispartof><rights>COPYRIGHT 2011 Public Library of Science</rights><rights>2011 Kraeussling et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Kraeussling et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c757t-3445f62b87b230bcb2335c7a923329f79b40ed71f21cf9bf6cb147b9b446cf4c3</citedby><cites>FETCH-LOGICAL-c757t-3445f62b87b230bcb2335c7a923329f79b40ed71f21cf9bf6cb147b9b446cf4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131289/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131289/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53770,53772,79347,79348</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21750728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Heisenberg, Carl-Philipp</contributor><creatorcontrib>Kraeussling, Michael</creatorcontrib><creatorcontrib>Wagner, Toni Ulrich</creatorcontrib><creatorcontrib>Schartl, Manfred</creatorcontrib><title>Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>Blastula</subject><subject>Blastula - cytology</subject><subject>Blastula - embryology</subject><subject>Blastula - metabolism</subject><subject>Caenorhabditis elegans</subject><subject>Cell cycle</subject><subject>Cell Cycle - genetics</subject><subject>Cell division</subject><subject>Cell Division - genetics</subject><subject>Cyclin B1 - genetics</subject><subject>Embryo, Nonmammalian - cytology</subject><subject>Embryo, Nonmammalian - embryology</subject><subject>Embryo, Nonmammalian - metabolism</subject><subject>Embryonic development</subject><subject>Embryos</subject><subject>Fish</subject><subject>Fish Proteins - genetics</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genetic aspects</subject><subject>Helobdella triserialis</subject><subject>Histology</subject><subject>Laboratories</subject><subject>Localization</subject><subject>Microscopy, Confocal</subject><subject>Mitochondrial Proteins - genetics</subject><subject>Oryzias - embryology</subject><subject>Oryzias - genetics</subject><subject>Oryzias - metabolism</subject><subject>Oryzias latipes</subject><subject>Phosphorylation</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Ribosomal Proteins - genetics</subject><subject>RNA polymerase</subject><subject>RNA Polymerase II - metabolism</subject><subject>Synchronization</subject><subject>Time Factors</subject><subject>Transcription</subject><subject>Transcription (Genetics)</subject><subject>Transcription, Genetic</subject><subject>Zebrafish</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11rFDEUhgdRbK3-A9EBQfFi13zNZOZGKEXtQqHg1204k0l2UzPJmsws7oX_3bN2W7rSCwkkwznP-2ZyklMUzymZUy7pu6s4pQB-vo7BzAlhVAr6oDimLWezmhH-8M73UfEk5ytCKt7U9ePiCOGKSNYcF7_P3XLltyXkbdCrFEOccgmh3wWGwYzJ6VJ7AxtYmrJ3G5ddDEhoHYc1hG1pIKF8TBCyTm49Yho85kdkx23pQrlOZtZ5yOPkoRxMDz-gNEOXtjE_LR5Z8Nk8268nxbePH76enc8uLj8tzk4vZlpWcpxxISpbs66RHeOk0zjzSktocWWtlW0niOkltYxq23a21h0VssOwqLUVmp8UL6991z5mta9cVpSTikkqKUdicU30Ea7UOrkB0lZFcOpvIKalgjQ6LIUSfWtAE91o9AZrWioIqxlYwevWNhV6vd_vNnV4Xm0ClscfmB5mglupZdwoTjllTYsGb_YGKf6cTB7V4LI23kMweD-qkbVsBG1qJF_9Q95_uD21BPx_F2zEbfXOU50KWTdNzdodNb-HwtGbwWl8ZdZh_EDw9kCAzGh-jUuYclaLL5__n738fsi-vsOuDPhxlaOfdm8rH4LiGtQp5pyMva0xJWrXJDfVULsmUfsmQdmLu_dzK7rpCv4HZyEP3Q</recordid><startdate>20110707</startdate><enddate>20110707</enddate><creator>Kraeussling, Michael</creator><creator>Wagner, Toni Ulrich</creator><creator>Schartl, Manfred</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20110707</creationdate><title>Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos</title><author>Kraeussling, Michael ; Wagner, Toni Ulrich ; Schartl, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c757t-3445f62b87b230bcb2335c7a923329f79b40ed71f21cf9bf6cb147b9b446cf4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biology</topic><topic>Blastula</topic><topic>Blastula - cytology</topic><topic>Blastula - embryology</topic><topic>Blastula - metabolism</topic><topic>Caenorhabditis elegans</topic><topic>Cell cycle</topic><topic>Cell Cycle - genetics</topic><topic>Cell division</topic><topic>Cell Division - genetics</topic><topic>Cyclin B1 - genetics</topic><topic>Embryo, Nonmammalian - cytology</topic><topic>Embryo, Nonmammalian - embryology</topic><topic>Embryo, Nonmammalian - metabolism</topic><topic>Embryonic development</topic><topic>Embryos</topic><topic>Fish</topic><topic>Fish Proteins - genetics</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Genetic aspects</topic><topic>Helobdella triserialis</topic><topic>Histology</topic><topic>Laboratories</topic><topic>Localization</topic><topic>Microscopy, Confocal</topic><topic>Mitochondrial Proteins - genetics</topic><topic>Oryzias - embryology</topic><topic>Oryzias - genetics</topic><topic>Oryzias - metabolism</topic><topic>Oryzias latipes</topic><topic>Phosphorylation</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Ribosomal Proteins - genetics</topic><topic>RNA polymerase</topic><topic>RNA Polymerase II - metabolism</topic><topic>Synchronization</topic><topic>Time Factors</topic><topic>Transcription</topic><topic>Transcription (Genetics)</topic><topic>Transcription, Genetic</topic><topic>Zebrafish</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraeussling, Michael</creatorcontrib><creatorcontrib>Wagner, Toni Ulrich</creatorcontrib><creatorcontrib>Schartl, Manfred</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraeussling, Michael</au><au>Wagner, Toni Ulrich</au><au>Schartl, Manfred</au><au>Heisenberg, Carl-Philipp</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2011-07-07</date><risdate>2011</risdate><volume>6</volume><issue>7</issue><spage>e21741</spage><epage>e21741</epage><pages>e21741-e21741</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>In the initial phase of development of fish embryos, a prominent and critical event is the midblastula transition (MBT). Before MBT cell cycle is rapid, highly synchronous and zygotic gene transcription is turned off. Only during MBT the cell cycle desynchronizes and transcription is activated. Multiple mechanisms, primarily the nucleocytoplasmic ratio, are supposed to control MBT activation. Unexpectedly, we find in the small teleost fish medaka (Oryzias latipes) that at very early stages, well before midblastula, cell division becomes asynchronous and cell volumes diverge. Furthermore, zygotic transcription is extensively activated already after the 64-cell stage. Thus, at least in medaka, the transition from maternal to zygotic transcription is uncoupled from the midblastula stage and not solely controlled by the nucleocytoplasmic ratio.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>21750728</pmid><doi>10.1371/journal.pone.0021741</doi><tpages>e21741</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2011-07, Vol.6 (7), p.e21741-e21741 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1305271713 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Biochemistry Biology Blastula Blastula - cytology Blastula - embryology Blastula - metabolism Caenorhabditis elegans Cell cycle Cell Cycle - genetics Cell division Cell Division - genetics Cyclin B1 - genetics Embryo, Nonmammalian - cytology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - metabolism Embryonic development Embryos Fish Fish Proteins - genetics Gene expression Gene Expression Regulation, Developmental Genetic aspects Helobdella triserialis Histology Laboratories Localization Microscopy, Confocal Mitochondrial Proteins - genetics Oryzias - embryology Oryzias - genetics Oryzias - metabolism Oryzias latipes Phosphorylation Reverse Transcriptase Polymerase Chain Reaction Ribosomal Proteins - genetics RNA polymerase RNA Polymerase II - metabolism Synchronization Time Factors Transcription Transcription (Genetics) Transcription, Genetic Zebrafish |
| title | Highly asynchronous and asymmetric cleavage divisions accompany early transcriptional activity in pre-blastula medaka embryos |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T03%3A01%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Highly%20asynchronous%20and%20asymmetric%20cleavage%20divisions%20accompany%20early%20transcriptional%20activity%20in%20pre-blastula%20medaka%20embryos&rft.jtitle=PloS%20one&rft.au=Kraeussling,%20Michael&rft.date=2011-07-07&rft.volume=6&rft.issue=7&rft.spage=e21741&rft.epage=e21741&rft.pages=e21741-e21741&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0021741&rft_dat=%3Cgale_plos_%3EA476886293%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1305271713&rft_id=info:pmid/21750728&rft_galeid=A476886293&rft_doaj_id=oai_doaj_org_article_4d9eac0c8ccf4afe9140262af4369f85&rfr_iscdi=true |