Immune responses to the enduring hypoxic response antigen Rv0188 are preferentially detected in Mycobacterium bovis infected cattle with low pathology

The DosR regulon and the Enduring Hypoxic Response (EHR) define a group of M. tuberculosis genes that are specifically induced in bacilli exposed in vitro to conditions thought to mimic the environment encountered by Mycobacteria during latent infection. Although well described in humans, latent myc...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e21371-e21371
Hauptverfasser:	Jones, Gareth J, Pirson, Chris, Gideon, Hannah P, Wilkinson, Katalin A, Sherman, David R, Wilkinson, Robert J, Hewinson, R Glyn, Vordermeier, H Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Bacterial - genetics Antigens, Bacterial - immunology Bacilli Bacteriology Beef cattle Bovidae Cattle Cytokines Cytokines - immunology Development and progression Disease control ESAT-6 antigen Genetic aspects Hierarchies Humans Hypoxia Immune response Immune system Immunotherapy Infection Infections Infectious diseases Inflammation Interferon Interferon-gamma - immunology Interleukin 2 Interleukin-2 - immunology Laboratories Latency Latent infection Medical records Medical research Medicine Mycobacterium bovis Mycobacterium bovis - immunology Mycobacterium tuberculosis Pathogens Pathology Peptides Peptides - genetics Peptides - immunology Proteins Regulon Skin Studies Tuberculosis Tuberculosis, Bovine - immunology Tuberculosis, Bovine - microbiology Tuberculosis, Bovine - pathology Veterinary Science γ-Interferon
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