Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action

The present study was designed to determine the biological effects of novel marine alkaloid analog 7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo[4,3,2-de]quinolin-8(1H)-one (FBA-TPQ) on human ovarian cancer cells for its anti-tumor potential and the underlying mechanisms as a novel chemotherapeu...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e20729
Hauptverfasser:	Chen, Tao, Xu, Yi, Guo, He, Liu, Yanling, Hu, Pingting, Yang, Xinying, Li, Xiaoguang, Ge, Shichao, Velu, Sadanandan E, Nadkarni, Dwayaja H, Wang, Wei, Zhang, Ruiwen, Wang, Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Analysis Animal models Animals Annexin V Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Apoptosis Apoptosis - drug effects Biocompatibility Biological effects Biology Cancer Cancer treatment Cell cycle Cell Cycle - drug effects Cell Line, Tumor Cell proliferation Chemical compounds Cytotoxicity Data analysis Data processing Dose-Response Relationship, Drug Epithelial cells Female Genomes Health aspects Humans In vivo methods and tests Information management Kinases MDM2 protein Medicine Membrane Potential, Mitochondrial - drug effects Mice Molecular modelling Nutrition Ovarian cancer Ovarian carcinoma Ovarian Neoplasms - pathology Oxygen p53 Protein Pharmacology Pyrroles - chemistry Pyrroles - pharmacology Quinolones - chemistry Quinolones - pharmacology Reactive oxygen species Rodents Signal Transduction - drug effects Toxicity Tumor proteins Tumors Xenograft Model Antitumor Assays Xenografts Xenotransplantation
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