Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia

Chlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety in G6PD deficient patients. This trial was conducted in 2004 to evaluate the safety and effectiveness of CD and comparison with artemether-lumefantrine (AL) under conditions of ro...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e17371
Hauptverfasser:	Dunyo, Samuel, Sirugo, Giorgio, Sesay, Sanie, Bisseye, Cyrille, Njie, Fanta, Adiamoh, Majidah, Nwakanma, Davis, Diatta, Mathurin, Janha, Ramatoulie, Sisay Joof, Fatou, Temple, Beth, Snell, Paul, Conway, David, Walton, Robert, Cheung, Yin Bun, Milligan, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anemia Animals Antimalarials - adverse effects Antimalarials - pharmacology Antimalarials - therapeutic use Artemether Artemether, Lumefantrine Drug Combination Artemisinins - adverse effects Artemisinins - pharmacology Artemisinins - therapeutic use Aryl Hydrocarbon Hydroxylases - genetics Case-Control Studies Child Children Chlorproguanil Councils Cytochrome P-450 CYP2C19 Dapsone Dapsone - adverse effects Dapsone - pharmacology Dapsone - therapeutic use Dehydrogenases Drug Combinations Drug dosages Drugs Epidemiology Ethanolamines - adverse effects Ethanolamines - pharmacology Ethanolamines - therapeutic use Female Fluorenes - adverse effects Fluorenes - pharmacology Fluorenes - therapeutic use Gambia - epidemiology Genetic diversity Genetic variance Genotype Genotypes Glucose Glucosephosphate dehydrogenase Glucosephosphate Dehydrogenase - genetics Hemoglobin Hemoglobins Hemoglobins - metabolism Humans Hygiene Incidence Infant Laboratories Malaria Malaria - drug therapy Malaria - enzymology Malaria - epidemiology Malaria - parasitology Male Maternal & child health Medical research Medicine Metabolism Parasites Parasites - drug effects Patient Compliance Patients Physiological aspects Population Proguanil - adverse effects Proguanil - analogs & derivatives Proguanil - pharmacology Proguanil - therapeutic use Risk Safety Treatment Failure Treatment Outcome Trends Vector-borne diseases
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