Variation in human recombination rates and its genetic determinants

Despite the fundamental role of crossing-over in the pairing and segregation of chromosomes during human meiosis, the rates and placements of events vary markedly among individuals. Characterizing this variation and identifying its determinants are essential steps in our understanding of the human r...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e20321
Hauptverfasser:	Fledel-Alon, Adi, Leffler, Ellen Miranda, Guan, Yongtao, Stephens, Matthew, Coop, Graham, Przeworski, Molly
Format:	Artikel
Sprache:	eng
Schlagworte:	Autism Biology Cardiovascular disease Chromosomes Crossing-over Female Females Genes Genetic diversity Genetic recombination Genetic variance Genome-wide association studies Genome-Wide Association Study Genomes Genomics Heart Humans Loci Male Males Meiosis Mitochondrial DNA Pedigree Phenotype Phenotypic variations Population Public health Recombination Recombination, Genetic Spermatogenesis White People
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