Impact of metabolic regulators on the expression of the obesity associated genes FTO and NAMPT in human preadipocytes and adipocytes

FTO and NAMPT/PBEF/visfatin are thought to play a role in obesity but their transcriptional regulation in adipocytes is not fully understood. In this study, we evaluated the transcriptional regulation of FTO and NAMPT in preadipocytes and adipocytes by metabolic regulators. We assessed FTO mRNA expr...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e19526-e19526
Hauptverfasser:	Friebe, Daniela, Löffler, Dennis, Schönberg, Maria, Bernhard, Falk, Büttner, Petra, Landgraf, Kathrin, Kiess, Wieland, Körner, Antje
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes Adipocytes - cytology Adipocytes - enzymology Adipocytes - metabolism Adipogenesis - genetics Adult Alpha-Ketoglutarate-Dependent Dioxygenase FTO Biology Biosynthesis Cell culture Cell Differentiation Cell division Cytokines Dexamethasone Differentiation Experiments Gene expression Gene Expression Regulation, Enzymologic Gene regulation Genes Glucose Humans Insulin Insulin resistance Insulin-like growth factor I Insulin-like growth factors Isoproterenol Kinases Male Medical research Medicine Messenger RNA Metabolism Middle Aged Nicotinamide Phosphoribosyltransferase - genetics Obesity Obesity - genetics Preadipocytes Proteins Proteins - genetics Rodents Signal transduction Teenagers Transcription Transcription, Genetic Type 2 diabetes Young Adult
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