Retinoic Acid signalling and the control of meiotic entry in the human fetal gonad

The development of mammalian fetal germ cells along oogenic or spermatogenic fate trajectories is dictated by signals from the surrounding gonadal environment. Germ cells in the fetal testis enter mitotic arrest, whilst those in the fetal ovary undergo sex-specific entry into meiosis, the initiation...

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Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e20249-e20249
Hauptverfasser:	Childs, Andrew J, Cowan, Gillian, Kinnell, Hazel L, Anderson, Richard A, Saunders, Philippa T K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Adaptor Proteins, Signal Transducing Analysis Androgens Animals Apoptosis Biology Cell cycle Cell differentiation Councils Cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Dehydrogenases Differentiation (biology) Enzymes Female Fetus - cytology Fetus - enzymology Fetus - metabolism Fetuses Gene expression Gene Expression Regulation Genes Germ cells Germ Cells - cytology Germ Cells - enzymology Germ Cells - metabolism Gestation Humans Immunohistochemistry Ligands Localization Male Medical research Meiosis Meiosis - genetics Metabolism Mice Ovary - cytology Ovary - enzymology Ovary - growth & development Ovary - metabolism Physiological aspects Pregnancy Pregnancy Trimester, Second - genetics Protein Transport Proteins Proteins - genetics Receptors Receptors, Retinoic Acid - genetics Regulators Retinal Dehydrogenase - genetics Retinal Dehydrogenase - metabolism Retinoic acid Retinoic Acid 4-Hydroxylase Retinoic acid receptors RNA-Binding Proteins - genetics Sex Characteristics Signal transduction Signal Transduction - genetics Signaling Testis - cytology Testis - enzymology Testis - growth & development Testis - metabolism Tretinoin Tretinoin - metabolism
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