Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction

Chronic kidney disease and end-stage renal disease are major causes of morbidity and mortality that are seen far more commonly in the aged population. Interestingly, kidney function declines during aging even in the absence of underlying renal disease. Declining renal function has been associated wi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2011-06, Vol.6 (6), p.e20411-e20411
Hauptverfasser:	Hernández-Corbacho, María José, Jenkins, Russell W, Clarke, Christopher J, Hannun, Yusuf A, Obeid, Lina M, Snider, Ashley J, Siskind, Leah J
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Age Aged, 80 and over Aging Aging - metabolism Aging - physiology Animals Apoptosis Biochemistry Biology Brain Caloric Restriction Ceramides Ceramides - metabolism Chains Chromatography Chronic kidney failure Diabetes Dietary restrictions E coli End-stage renal disease Escherichia coli Female Fibroblasts Fibroblasts - metabolism Gene expression Geriatrics Glycosphingolipids Glycosphingolipids - chemistry Glycosphingolipids - metabolism Health aspects House mouse Humans Hypotheses Inflammation Kidney diseases Kidneys Laboratory animals Lipids Liver Male Mammals Mass spectrometry Medicine Metabolism Mice Mice, Inbred C57BL Middle Aged Molecular biology Morbidity Nephrology Older people Organ Specificity Organs Oxidative stress Oxidoreductases - metabolism Physiological aspects Population decline Prevention Quantitative analysis Renal function Rodents Scientific imaging Senescence Sphingolipids Sphingomyelin Phosphodiesterase - metabolism Veterans Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!